FOLR1 Antibody (548908) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37‑42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown (1, 2). Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage (3‑6). Human FOLR1 shares 83% amino acid sequence identity with mouse and rat FOLR1.  FOLR1 is predominantly expressed on epithelial cells and is dramatically up‑regulated on many carcinomas (7, 8). It is critically required during early embryogenesis as shown in knockout mice which die in utero with gross morphological defects (9). FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface (6, 10). A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk (11).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 6 applications: ELISA Capture, ELISA Detection, ELISA Development, ELISA Development (Capture), Flow Cytometry, Western Blot.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using MAB5646	Applications	Species
Spicer, J;Basu, B;Montes, A;Banerji, U;Kristeleit, R;Miller, R;Veal, GJ;Corrigan, CJ;Till, SJ;Figini, M;Canevari, S;Barton, C;Jones, P;Mellor, S;Carroll, S;Selkirk, C;Nintos, G;Kwatra, V;Funingana, IG;Doherty, G;Gould, HJ;Pellizzari, G;Nakamura, M;Ilieva, KM;Khiabany, A;Stavraka, C;Chauhan, J;Gillett, C;Pinder, S;Bax, HJ;Josephs, DH;Karagiannis, SN; Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial Nature communications 2023-07-25 [PMID: 37491373] (ELISA Capture, Human)	ELISA Capture	Human
Yokoi, A;Ukai, M;Yasui, T;Inokuma, Y;Hyeon-Deuk, K;Matsuzaki, J;Yoshida, K;Kitagawa, M;Chattrairat, K;Iida, M;Shimada, T;Manabe, Y;Chang, IY;Asano-Inami, E;Koya, Y;Nawa, A;Nakamura, K;Kiyono, T;Kato, T;Hirakawa, A;Yoshioka, Y;Ochiya, T;Hasegawa, T;Baba, Y;Yamamoto, Y;Kajiyama, H; Identifying high-grade serous ovarian carcinoma-specific extracellular vesicles by polyketone-coated nanowires Science advances 2023-07-07 [PMID: 37418532] (Western Blot, Human)	Western Blot	Human
HJ Bax, J Chauhan, C Stavraka, A Santaolall, G Osborn, A Khiabany, M Grandits, J López-Aben, LCGF Palhares, C Chan Wah H, A Robinson, A Pope, N Woodman, C Naceur-Lom, S Malas, JEM Coumbe, M Nakamura, R Laddach, S Mele, S Crescioli, AM Black, S Lombardi, S Canevari, M Figini, A Sayasneh, S Tsoka, K FitzGerald, C Gillett, S Pinder, M Van Hemelr, R Kristeleit, S Ghosh, A Montes, J Spicer, SN Karagianni, DH Josephs Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes British Journal of Cancer, 2022-11-19;0(0):. 2022-11-19 [PMID: 36402875] (ELISA Capture, Human)	ELISA Capture	Human
J Song, LJ Sokoll, DW Chan, Z Zhang Validation of Serum Biomarkers That Complement CA19-9 in Detecting Early Pancreatic Cancer Using Electrochemiluminescent-Based Multiplex Immunoassays Biomedicines, 2021-12-14;9(12):. 2021-12-14 [PMID: 34944713] (ELISA Capture, ELISA Detection, Human)	ELISA Capture, ELISA Detection	Human
T Mondal, GN Shivange, RG Tihagam, E Lyerly, M Battista, D Talwar, R Mosavian, K Urbanek, NS Rashid, JC Harrell, PD Bos, EB Stelow, MS Stack, S Bhatnagar, J Tushir-Sin Unexpected PD-L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies Embo Molecular Medicine, 2021-02-15;13(3):e12716. 2/15/2021 [PMID: 33587338]
Na Li, Hao Zuo, Luojun Chen, Huali Liu, Jin Zhou, Yi Yao et al. <p>Circulating Tumor Cell Detection In Epithelial Ovarian Cancer Using Dual-Component Antibodies Targeting EpCAM And FR alpha </p> Cancer Management and Research 1/1/2020 [PMID: 32021417]
K Taniuchi, T Yawata, M Tsuboi, T Ueba, T Saibara Efficient delivery of small interfering RNAs targeting particular mRNAs into pancreatic cancer cells inhibits invasiveness and metastasis of pancreatic tumors Oncotarget, 2019-04-23;10(30):2869-2886. 2019-04-23 [PMID: 31080558] (Western Blot, Human)	Western Blot	Human
Luojun Chen, Min Peng, Na Li, Qibin Song, Yi Yao, Bin Xu et al. Combined use of EpCAM and FR alpha enables the high-efficiency capture of circulating tumor cells in non-small cell lung cancer Scientific Reports 1/19/2018 [PMID: 29352248]
Giovanni Roti, Jun Qi, Samuel Kitara, Marta Sanchez-Martin, Amy Saur Conway, Anthony C. Varca et al. Leukemia-specific delivery of mutant NOTCH1 targeted therapy Journal of Experimental Medicine 1/2/2018 [PMID: 29158376]
Promising Nanocarriers for PEDF Gene Targeting Delivery to Cervical Cancer Cells Mediated by the Over-expressing FR? Sci Rep, 2016-08-31;6(0):32427. 2016-08-31 [PMID: 27576898] (Flow Cytometry, Human)	Flow Cytometry	Human
Kelemen L, Brenton J, Parkinson C, C Whitaker H, Piskorz A, Csizmadi I, Robson P Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women. PLoS ONE, 2014-05-08;9(5):e96542. 2014-05-08 [PMID: 24810481] (ELISA Development (Capture), Human)	ELISA Development (Capture)	Human
Rudman SM, Josephs DH, Cambrook H, Karagiannis P, Gilbert AE, Dodev T, Hunt J, Koers A, Montes A, Taams L, Canevari S, Figini M, Blower PJ, Beavil AJ, Nicodemus CF, Corrigan C, Kaye SB, Nestle FO, Gould HJ, Spicer JF, Karagiannis SN Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcvarepsilonRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity. Clin. Exp. Allergy, 2011-05-16;41(10):1400-1413. 2011-05-16 [PMID: 21569129] (ELISA Development, Human)	ELISA Development	Human
Show All 12 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	Flow	Human	04/07/2019	View Summary Application Flow Cytometry Sample Tested IGROV cell line,IGROV1 cell line Species Human Lot CCQX0817111
Enlarge	5 reviewed by: Verified Customer	Flow	Human	03/21/2018	View Summary Application Flow Cytometry Sample Tested Human cancer cell line Species Human Lot CCQX0817111

Array MAB5646

• FOLR1 Antibodies
• FOLR1 Antibody Pair
• FOLR1 Lysates
• FOLR1 ELISAs
• FOLR1 Proteins and Enzymes