Reactivity | HuSpecies Glossary |
Applications | Flow, CyTOF-ready |
Clone | 1000624 |
Clonality | Monoclonal |
Host | Mouse |
Conjugate | Unconjugated |
Immunogen | NS0 Mouse myeloma cell line transfected with human FFAR2/GPR43 Met1-Glu330 Accession # O15552 |
Specificity | Stains human FFAR2/GPR43 transfectants but not irrelevant transfectants in flow cytometry. |
Source | N/A |
Isotype | IgG2b |
Clonality | Monoclonal |
Host | Mouse |
Purity Statement | Protein A or G purified from hybridoma culture supernatant |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Publications |
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Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Reconstitution Instructions | Reconstitute at 0.5 mg/mL in sterile PBS. |
Human Free fatty acid receptor 2 (FFA2, FFAR2, GPCR43 or GPR43) is a 330 aminoacids G-protein coupled receptor encoded by the FFAR2 gene. G-protein-coupled receptors (GPCRs) are seven-trans-membrane (7TM) receptors that mediate cellular responses to the majority of hormones and neurotransmitters and are common targets for drug discovery. Human GPR43/FFA2 is present in a large variety of tissues, including adipose tissue, inflammatory cells, and gastrointestinal (GI) tract and is activated by short-chain fatty acids (SCFAs). Studies on knockout mice have identified Free Fatty Acid Receptor 2 (FFAR2 or GPR43) as a critical gene in the prevention of obesity, colitis, asthma and arthritis.
Publication using MAB10082 | Applications | Species |
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Thomas SP, Denu JM. Short-chain fatty acids activate acetyltransferase p300 eLife 2021-10-22 [PMID: 34677127] |
Secondary Antibodies |
Isotype Controls |
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