ERO1L Antibody (4G3)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Perhaps the most distinctive feature of protein folding in the ER is the abundance of disulfide bonds that must form during maturation of proteins traveling along the secretory pathway. Formation of disulfide bonds is a redox reaction. Thus, to match the flux of disulfide bonds that exit from the ER by virtue of protein secretion, a flux of oxidizing equivalents into the ER is required. In eukaryotic cells, the essential protein relay supporting this flux, and hence disulfide bond formation, involves endoplasmic reticulum oxidoreductin 1 (Ero1) and protein disulfide isomerase (PDI). The temporal pattern of hypoxic ERO1-L alpha induction is very similar to that of genes triggered by the hypoxia inducible transcription factor (HIF-1) and is characteristically mimicked by cobalt and by deferoxamine, but is absent in cells with a defective aryl hydrocarbon receptor translocator (ARNT, HIF-1 alpha). We speculate from these findings that the expression of ERO1-L alpha is probably regulated via the HIF-pathway and thus belongs to the family of classic oxygen regulated genes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using H00030001-M01	Applications	Species
Fenglei C, Jiarong S, Yujing W et al. Silica nanoparticles induce ovarian granulosa cell apoptosis via activation of the PERK-ATF4-CHOP-ERO1? pathway-mediated IP3R1-dependent calcium mobilization. Cell Biol Toxicol. 2022-11-08 [PMID: 36346508]
F Zilli, P Marques Ra, P Auf der Ma, C Jehanno, A Sethi, MM Coissieux, T Eichlisber, L Sauteur, A Rouchon, L Bonapace, J Pinto Cout, R Rad, MR Jensen, A Banfi, MB Stadler, M Bentires-A The NFIB-ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells Embo Molecular Medicine, 2021-03-10;0(0):e13162. 2021-03-10 [PMID: 33751828]
Hu J, Jin J, Qu Y et al. ERO1? inhibits cell apoptosis and regulates steroidogenesis in mouse granulosa cells. Mol Cell Endocrinol. 2020-05-04 [PMID: 32376276]
Chen F, Wang Y, Liu Q et al. ERO1? promotes testosterone secretion in hCG-stimulated mouse Leydig cells via activation of the PI3K/AKT/mTOR signaling pathway. J Cell Physiol. 2020-01-28 [PMID: 31990068]
Takei N, Yoneda A, Kosaka M et al. ERO1? is a novel endogenous marker of hypoxia in human cancer cell lines. BMC Cancer. 2019-05-29 [PMID: 31142270]
Kim K, An A, Park H et al. Combined expression of protein disulfide isomerase and endoplasmic reticulum oxidoreductin 1-? is a poor prognostic marker for non-small cell lung cancer. Oncol Lett. 2018-08-21 [PMID: 30344729]
Kim J, Haque MN, Goo TW et al. Alleviation of Hippocampal Endoplasmic Reticulum Stress by Allomyrina dichotoma Larvae Extract. Am J Chin Med 2018-03-29 [PMID: 29595074]
Kim J, Yun EY, Quan FS et al. Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity. Evid Based Complement Alternat Med 2017-07-17 [PMID: 28798799]
Hsu CH, Hsu CW, Hsueh C et al. Identification and Characterization of Potential Biomarkers by Quantitative Tissue Proteomics of Primary Lung Adenocarcinoma. Mol Cell Proteomics 2016-07-01 [PMID: 27161446]
Tanaka T, Kutomi G, Kajiwara T et al. Cancer-associated oxidoreductase ERO1-alpha drives the production of VEGF via oxidative protein folding and regulating the mRNA level. Br J Cancer 2016-04-21 [PMID: 27100727]
Kim J, Yun EY, Park SW et al. Allomyrina Dichotoma Larvae Regulate Food Intake and Body Weight in High Fat Diet-Induced Obese Mice Through mTOR and Mapk Signaling Pathways. Nutrients 2016-02-18 [PMID: 26901224]
Araki K, Iemura S, Kamiya Y et al. Ero1-alpha and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases. J Cell Biol. 2013-09-16 [PMID: 24043701] (Human)		Human
Show All 12 Publications. Collapse Publications.

Array H00030001-M01

• ERO1L Antibodies
• ERO1L Lysate
• ERO1L Proteins
• ERO1L Proteins and Enzyme