Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: Enzyme Activity
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Description
Perhaps the most distinctive feature of protein folding in the ER is the abundance of disulfide bonds that must form during maturation of proteins traveling along the secretory pathway. Formation of disulfide bonds is a redox reaction. Thus, to match the flux of disulfide bonds that exit from the ER by virtue of protein secretion, a flux of oxidizing equivalents into the ER is required. In eukaryotic cells, the essential protein relay supporting this flux, and hence disulfide bond formation, involves endoplasmic reticulum oxidoreductin 1 (Ero1) and protein disulfide isomerase (PDI). The temporal pattern of hypoxic ERO1-L alpha induction is very similar to that of genes triggered by the hypoxia inducible transcription factor (HIF-1) and is characteristically mimicked by cobalt and by deferoxamine, but is absent in cells with a defective aryl hydrocarbon receptor translocator (ARNT, HIF-1 alpha). We speculate from these findings that the expression of ERO1-L alpha is probably regulated via the HIF-pathway and thus belongs to the family of classic oxygen regulated genes.
Bioinformatics
Entrez |
Rat Human Mouse |
Uniprot |
Human Human Human |
Product By Gene ID |
30001 |
Alternate Names |
- EC 1.8.4
- EC 1.8.4.-
- Endoplasmic oxidoreductin-1-like protein
- ERO1 (S. cerevisiae)-like
- ERO1A
- ERO1-alpha
- ERO1-L
- ERO1-L-alpha
- ERO1-like (S. cerevisiae)
- ERO1-like protein alpha
- Oxidoreductin-1-L-alpha
- oxidoreductin-1-L-alpha
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