EAAT2/GLT1 Antibody

SLC1A2 is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC-P, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP1-59632	Applications	Species
Herrera Moro Chao D, Kirchner MK, Pham C et al. Hypothalamic astrocytes control systemic glucose metabolism and energy balance Cell metabolism 2022-10-04 [PMID: 36198294]
Singal CMS, Jaiswal P, Mehta A Et al. Role of EphrinA3 in HIV-1 Neuropathogenesis ASN neuro 2021-10-07 [PMID: 34618621] (WB, Human)	WB	Human
Pallottie A, Ratnayake A, Ni L et al. A toll-like receptor 9 antagonist restores below-level glial glutamate transporter expression in the dorsal horn following spinal cord injury. Sci Rep 2018-06-07 [PMID: 29880832] (WB, Mouse)	WB	Mouse
Garcia-Berrocoso T, Llombart V, Colas-Campas L et al. Single Cell Immuno-laser Microdissection Coupled to Label-free Proteomics to Reveal the Proteotypes of Human Brain Cells After Ischemia Mol. Cell Proteomics. 2017-11-13 [PMID: 29133510] (IHC-P, Human)	IHC-P	Human
Fawzi AA, Simonett JM, Purta P et al. Clinicopathologic report of ocular involvement in ALS patients with C9orf72 mutation. Amyotroph Lateral Scler Frontotemporal Degener. 2014-10-16 [PMID: 25319030] (IHC-P, Human)	IHC-P	Human

Array NBP1-59632

• EAAT2/GLT1 Antibodies
• EAAT2/GLT1 ELISA Kits
• EAAT2/GLT1 Lysate
• EAAT2/GLT1 Proteins