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Dtk/TYRO3 Antibody (96201) [Alexa Fluor® 488]

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K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human Dtk Alexa Fluor® 488-conjugated Monoclonal Antibody (Catalog # FAB859G, filled histogram) or isotype control antibody (IC002G, open histogram). Staining was performed using our Staining Membrane-associated Proteins protocol.
K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human Dtk Alexa Fluor® 488-conjugated Monoclonal Antibody (Catalog # FAB859G, filled histogram) or isotype control antibody (IC002G, ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
96201
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 488

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB859U-100UG
Alexa Fluor 405
FAB859V-100UG
Alexa Fluor 532
FAB859X
Alexa Fluor 594
FAB859T-100UG
Alexa Fluor 647
FAB859R-100UG
Alexa Fluor 700
FAB859N-100UG
Alexa Fluor 750
FAB859S-100UG
Allophycocyanin
FAB859A
Allophycocyanin/Cy7
FAB859APCCY7
Biotin
FAB859B
DyLight 350
FAB859D
DyLight 405
FAB859E
DyLight 488
FAB859K
DyLight 550
FAB859L
DyLight 594
FAB859M
DyLight 650
FAB859W
DyLight 680
FAB859Y
DyLight 755
FAB859Z
FITC
FAB859F
HRP
FAB859H
Janelia Fluor 549
FAB859I
Janelia Fluor 646
FAB859J
PE/Atto594
FAB859PEATT594
PE/Cy5.5
FAB859PECY55
PE/Cy7
FAB859PECY7
PerCP
FAB859C
Phycoerythrin
FAB859P
Unconjugated
MAB859-100
mFluor Violet 450 SE
FAB859MFV450
mFluor Violet 500 SE
FAB859MFV500
mFluor Violet 610 SE
FAB859MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB859-100
Carrier Free
FAB859P
Carrier Free
MAB859-SP
Carrier Free
MAB859-500
Carrier Free
MAB859-100
Carrier Free
FAB859S-100UG
Carrier Free
FAB859R-100UG
Carrier Free
FAB859U-100UG
Carrier Free
FAB859V-100UG
Carrier Free
FAB859T-100UG
Carrier Free
FAB859N-100UG
100% Guarantee on every product

Dtk/TYRO3 Antibody (96201) [Alexa Fluor® 488] Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Tyro3/Dtk
Ala41-Ser428 (predicted)
Accession # Q06418
Specificity
Detects human Tyro3/Dtk in ELISAs and Western blots. In ELISAs and Western blots, no cross-reactivity or interferance with recombinant mouse Tyro3/Dtk, recombinant human (rh) Axl, or rhMer is observed.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Reconstitution Instructions
Reconstitution default not known

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Dtk/TYRO3 Antibody (96201) [Alexa Fluor® 488]

  • Brt
  • BYK
  • Dtk
  • EC 2.7.10
  • EC 2.7.10.1
  • FLJ16467
  • Rse
  • Sky
  • Tif
  • TYRO3 protein tyrosine kinase
  • Tyro3
  • Tyrosine-protein kinase byk
  • Tyrosine-protein kinase DTK
  • tyrosine-protein kinase receptor TYRO3
  • Tyrosine-protein kinase RSE
  • Tyrosine-protein kinase SKY

Background

Dtk (also called Sky, Tyro3, Rse, Brt), Axl (Ufo, Ark) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. The binding affinities for Gas6 is in the order of Axl > Dtk > Mer. Gas6 binding induces tyrosine phosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Dtk is widely expressed during embryonic development. In adults, Dtk is predominantly expressed in neurons in restricted regions of the brain.

  1. Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
  2. Crosier, K.E. and P.S Crosier (1997) Pathology 29:131.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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