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Recombinant Human Tyro3/Dtk Fc Chimera Protein, CF

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 (1 Review)
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Summary
Reactivity HuSpecies Glossary
Applications Binding Activity
Format
Carrier-Free

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Recombinant Human Tyro3/Dtk Fc Chimera Protein, CF Summary

Details of Functionality
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Tyro3/Dtk Fc Chimera at 2 µg/mL (100 µL/well) can bind Recombinant Human Gas6 (Catalog # 885-GSB) with a linear range of 2-100 ng/mL.
Source
Mouse myeloma cell line, NS0-derived human Tyro3/Dtk protein
Human Tyro3/Dtk
(Ala41-Ser428)
Accession # Q06418		 DIEGRMD Human IgG1
(Pro100-Lys330) 		6-His tag
N-terminus C-terminus
Accession #
N-terminal Sequence
Ala41
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
Gene
TYRO3
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Binding Activity
Theoretical MW
69 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
100-110 kDa, reducing conditions
Reviewed Applications
Read 1 Review rated 5
using
859-DK in the following application:
Publications
Read Publications using
859-DK in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Tyro3/Dtk Fc Chimera Protein, CF

  • Brt
  • BYK
  • Dtk
  • EC 2.7.10
  • EC 2.7.10.1
  • FLJ16467
  • Rse
  • Sky
  • Tif
  • TYRO3 protein tyrosine kinase
  • Tyro3
  • Tyrosine-protein kinase byk
  • Tyrosine-protein kinase DTK
  • tyrosine-protein kinase receptor TYRO3
  • Tyrosine-protein kinase RSE
  • Tyrosine-protein kinase SKY

Background

Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. The binding affinities for Gas6 is in the order of Axl > Dtk > Mer. Gas6 binding induces tyrosine phosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Dtk is widely expressed during embryonic development. In adults, Dtk is predominantly expressed in neurons in restricted regions of the brain.

  1. Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
  2. Crosier, K.E. and P.S Crosier (1997) Pathology 29:131.

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Recombinant Human
Tyro3/Dtk Fc Chimera ...
859-DK
Recombinant Human Tyro3/Dtk Fc Chimera Protein, CF
Species: Hu
Applications: Binding Activity

Publications for Dtk/TYRO3 (859-DK)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Binding Assay, Bioassay.


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(1)
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(1)
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(2)
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Review for Dtk/TYRO3 (859-DK) (1) 51

Average Rating: 5
(Based on 1 review)

Reviews using 859-DK:
Filter by Applications
Binding assay/Protein-protein interaction
(1)
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Images Ratings Applications Species Date Details
Binding assay/Protein-protein interaction Dtk/TYRO3 859-DK
Enlarge 		5
reviewed by:
Verified Customer
 Binding assay/Protein-protein interaction 03/21/2018
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Summary

ApplicationBinding assay/Protein-protein interaction
LotCFQ0415051

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Binding assay/Protein-protein interaction Dtk/TYRO3 859-DK
Enlarge
 Verified Customer
03/21/2018
Application: Binding assay/Protein-protein interaction
Species:
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Bioinformatics

Gene Symbol TYRO3
Uniprot