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Dopamine D5R/DRD5 Antibody (889040)

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Dopamine D5 R/DRD5 was detected in immersion fixed paraffin-embedded sections of human brain using Mouse Anti-Human Dopamine D5 R/DRD5 Monoclonal Antibody (Catalog # MAB8286) at 15 µg/mL overnight at 4 °C. Tissue was ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
889040
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Formulation Size Price
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Dopamine D5R/DRD5 Antibody (889040) Summary

Immunogen
NS0 mouse myeloma cell line transfected with human Dopamine D5 R/DRD5
Accession # P21918
Specificity
Detects HEK293 cells transfected with human Dopamine D5 R/DRD5 by Flow Cytometry. Does not detect untransfected or irrelevant transfected HEK293 cells.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
DRD5
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 8-25 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Dopamine D5R/DRD5 Antibody (889040)

  • D(1B) dopamine receptor
  • D(5) dopamine receptor
  • D1beta dopamine receptor
  • DBDR
  • Dopamine D5 R
  • Dopamine D5 receptor
  • Dopamine D5R
  • dopamine receptor D1B
  • dopamine receptor D5
  • DRD1B
  • DRD1BDBDR
  • DRD1L2
  • DRD1L2MGC10601
  • DRD5

Background

DRD5, also known as Dopamine D5 Receptor has a higher affinity for neurotransmitter dopamine than DRD1 (1). DRD5 is expressed in neurons in many human brain regions, including cortex regions, hippocampus, choroid plexus, and brainstem (2). Polymorphisms in the DRD5 gene have been associated with Attention Deficit Hyperactivity Disorder (ADHD) (3), schizopherenia (4) and nicotine dependence (5). Dopamine receptors undergo endocytosis upon interaction with receptor agonists and by activation of protein kinase C (PKC) (6).
  1. Sunahra, R. et al. (1991) Nature.  350:614.
  2. Weinshank, R. et al. (1991) J Biol Chem. 266:22427.
  3. Squassina, A. et al.  (2008) Neurosci Lett.  Feb 13.
  4. Golimbet, V. et al.  (2008) Bull Exp Biol Med. Jan.
  5. Wei, J. et al.  (2012) Addict Behav. 37:622.
  6. Thompson, D. et al. (2011) Traffic. 12:644.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol DRD5
Uniprot