DC-SIGN/CD209 Antibody (902404) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Mouse Dendritic Cell-specific ICAM-3 Grabbing Non-integrin (DC-SIGN)/CD209, also known as CD209 Antigen-like Protein A, is a member of the C-type lectin family (1). Mouse DC-SIGN/CD209 is a 33 kDa, 238 amino acid (aa) type II transmembrane protein (2). The extracellular region contains a Ca²⁺-dependent carbohydrate-binding lectin domain (2). In addition to the full-length mouse DC-SIGN/CD209, a second, truncated splice variant has been reported. DC-SIGN/CD209 is not well conserved between mouse and human with the extracellular domain sharing only 63% aa identity. The DC-SIGN/CD209 lectin domain binds mannose oligosaccharides on pathogens including HIV as well as self glycoproteins including ICAMs (2-4). DC-SIGN/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation (2, 5, 6).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB8345

• DC-SIGN/CD209 Antibodies
• DC-SIGN/CD209 Antibody Pair
• DC-SIGN/CD209 ELISA Kit
• DC-SIGN/CD209 Lysate
• DC-SIGN/CD209 Proteins
• DC-SIGN/CD209 Proteins and Enzymes