Name: DC-SIGNR/CD299/CLEC4M Antibody (120604) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB162
Price: 549 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	Flow, B/N, CyTOF-ready
Clone	120604
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 FAB162U-100UG

Alexa Fluor 405 FAB162V-100UG

Alexa Fluor 488 FAB162G-100UG

Alexa Fluor 532 FAB162X

Alexa Fluor 594 FAB162T-100UG

Alexa Fluor 647 FAB162R-100UG

Alexa Fluor 700 FAB162N-100UG

Alexa Fluor 750 FAB162S-100UG

Allophycocyanin FAB162A

Allophycocyanin/Cy7 FAB162APCCY7

Biotin FAB162B

DyLight 350 FAB162D

DyLight 405 FAB162E

DyLight 488 FAB162K

DyLight 550 FAB162L

DyLight 594 FAB162M

DyLight 650 FAB162W

DyLight 680 FAB162Y

DyLight 755 FAB162Z

HRP FAB162H

Janelia Fluor 549 FAB162I

Janelia Fluor 646 FAB162J

PE/Atto594 FAB162PEATT594

PE/Cy5.5 FAB162PECY55

PE/Cy7 FAB162PECY7

PerCP FAB162C

Phycoerythrin FAB162P

Catalog# & Formulation	Size	Price
Carrier Free FAB162P

Carrier Free MAB162-SP

Carrier Free FAB162V-100UG

Carrier Free FAB162U-100UG

Carrier Free FAB162T-100UG

Carrier Free FAB162S-100UG

Carrier Free FAB162R-100UG

Carrier Free FAB162N-100UG

Carrier Free FAB162G-100UG

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB162U-100UG
Alexa Fluor 405	FAB162V-100UG
Alexa Fluor 488	FAB162G-100UG
Alexa Fluor 532	FAB162X
Alexa Fluor 594	FAB162T-100UG
Alexa Fluor 647	FAB162R-100UG
Alexa Fluor 700	FAB162N-100UG
Alexa Fluor 750	FAB162S-100UG
Allophycocyanin	FAB162A
Allophycocyanin/Cy7	FAB162APCCY7
Biotin	FAB162B
DyLight 350	FAB162D
DyLight 405	FAB162E
DyLight 488	FAB162K
DyLight 550	FAB162L
DyLight 594	FAB162M
DyLight 650	FAB162W
DyLight 680	FAB162Y
DyLight 755	FAB162Z
HRP	FAB162H
Janelia Fluor 549	FAB162I
Janelia Fluor 646	FAB162J
PE/Atto594	FAB162PEATT594
PE/Cy5.5	FAB162PECY55
PE/Cy7	FAB162PECY7
PerCP	FAB162C
Phycoerythrin	FAB162P

DC-SIGNR/CD299/CLEC4M Antibody (120604) [Unconjugated]

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DC-SIGNR/CD299/CLEC4M Antibody (120604) [Unconjugated] Summary

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Publications for DC-SIGNR/CD299/CLEC4M Antibody (MAB162)(17)

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Bioinformatics

Additional Information	Clone 120604 was used by HLDA to establish CD designation
Immunogen	NIH-3T3 mouse embryonic fibroblast cell line transfected with human DC‑SIGNR/CD299 Accession # Q9H2X3
Specificity	Detects human DC‑SIGNR/CD299.
Source	N/A
Isotype	IgG2b
Clonality	Monoclonal
Host	Mouse
Gene	CLEC4M
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Publications using MAB162	Applications	Species
Lei Guo, Yan Liang, Heng Li, Huiwen Zheng, Zening Yang, Yanli Chen et al. Epigenetic glycosylation of SARS-CoV-2 impact viral infection through DC&L-SIGN receptors iScience 12/17/2021 [PMID: 34786539]
AW Wessel, MP Doyle, TB Engdahl, J Rodriguez, JE Crowe, MS Diamond Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection MBio, 2021-10-12;12(5):e0244021. 2021-10-12 [PMID: 34634945] (Human)		Human
Y Kondo, JL Larabee, L Gao, H Shi, B Shao, CM Hoover, JM McDaniel, YC Ho, R Silasi-Man, SA Archer-Har, P Azadi, RS Srinivasan, AR Rezaie, A Borczuk, JC Laurence, F Lupu, J Ahamed, RP McEver, JF Papin, Z Yu, L Xia L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus JCI Insight, 2021-07-22;6(14):. 2021-07-22 [PMID: 34291736] (Flow Cytometry, Neutralization, Human)	Flow Cytometry, Neutralization	Human
Menglan Xiang, Rubén Adrián Grosso, Akira Takeda, Junliang Pan, Tove Bekkhus, Kevin Brulois et al. A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature Frontiers in Cardiovascular Medicine 4/30/2020 [PMID: 32426372]
MB Vogt, A Lahon, RP Arya, JL Spencer Cl, R Rico-Hesse Dengue viruses infect human megakaryocytes, with probable clinical consequences PLoS Negl Trop Dis, 2019-11-25;13(11):e0007837. 2019-11-25 [PMID: 31765380] (Flow Cytometry, Human)	Flow Cytometry	Human
Derek L. Carbaugh, Ralph S. Baric, Helen M. Lazear Envelope Protein Glycosylation Mediates Zika Virus Pathogenesis Journal of Virology 6/15/2019 [PMID: 30944176]
Goo L, Debbink K, Kose N et al. A protective human monoclonal antibody targeting the West Nile virus E protein preferentially recognizes mature virions. Nat Microbiol. 11/19/2018 [PMID: 30455471]
LL Swystun, JD Lai, C Notley, I Georgescu, AS Paine, J Mewburn, K Nesbitt, K Schledzews, C Géraud, J Kzhyshkows, S Goerdt, W Hopman, RR Montgomery, PD James, D Lillicrap The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity J. Clin. Invest., 2018-08-20;128(9):4057-4073. 2018-08-20 [PMID: 30124466] (Flow Cytometry, Human)	Flow Cytometry	Human
Mariko Ishibashi, Naoko Morita, Chisato Nomura-Kawaguchi, Yohko Shimizu, Takaji Wakita, Mariko Esumi CLEC4M-positive and CD81-negative Huh7 cells are not susceptible to JFH-1 HCVcc infection but mediate transinfection Archives of Virology 11/1/2014 [PMID: 24965233]
Johnson TR, McLellan JS, Graham BS Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2. J. Virol., 2011-11-16;86(3):1339-47. 2011-11-16 [PMID: 22090124] (Neutralization, Human)	Neutralization	Human
Crosby HA, Lalor PF, Ross E, Newsome PN, Adams DH Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4. J. Hepatol., 2009-07-30;51(4):734-49. 2009-07-30 [PMID: 19703720] (IHC, Human)	IHC	Human
Jain P, Manuel SL, Khan ZK, Ahuja J, Quann K, Wigdahl B DC-SIGN mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cells. J. Virol., 2009-08-19;83(21):10908-21. 2009-08-19 [PMID: 19692463] (Neutralization, Human)	Neutralization	Human
Chaipan C, Soilleux EJ, Simpson P, Hofmann H, Gramberg T, Marzi A, Geier M, Stewart EA, Eisemann J, Steinkasserer A, Suzuki-Inoue K, Fuller GL, Pearce AC, Watson SP, Hoxie JA, Baribaud F, Pohlmann S DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. J. Virol., 2006-09-01;80(18):8951-60. 2006-09-01 [PMID: 16940507] (Neutralization, Human)	Neutralization	Human
Falkowska E, Durso R, Gardner J, Cormier E, Arrigale R, Ogawa R, Donovan G, Maddon P, Olson W, Dragic T L-SIGN (CD209L) isoforms differently mediate trans-infection of hepatoma cells by hepatitis C virus pseudoparticles. J Gen Virol, 2006-09-01;87(0):2571-6. 2006-09-01 [PMID: 16894195] (Flow Cytometry, Human)	Flow Cytometry	Human
Karrar A, Broome U, Uzunel M, Qureshi AR, Sumitran-Holgersson S Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction. Gut, 2006-07-13;56(2):243-52. 2006-07-13 [PMID: 16840505] (IHC-Fr, Human)	IHC-Fr	Human
Lai WK, Sun PJ, Zhang J, Jennings A, Lalor PF, Hubscher S, McKeating JA, Adams DH Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. Am. J. Pathol., 2006-07-01;169(1):200-8. 2006-07-01 [PMID: 16816373] (IHC, Human)	IHC	Human
Ludwig IS, Lekkerkerker AN, Depla E, Bosman F, Musters RJ, Depraetere S, van Kooyk Y, Geijtenbeek TB Hepatitis C virus targets DC-SIGN and L-SIGN to escape lysosomal degradation. J. Virol., 2004-08-01;78(15):8322-32. 2004-08-01 [PMID: 15254204] (ICC, Human)	ICC	Human
Show All 17 Publications. Collapse Publications.

Gene Symbol	CLEC4M
Uniprot	Q9H2X3()