DAP Kinase 2 Antibody

DAPK2 is a 42 KDa calcium/calmodulin-dependent serine/threonine kinase localized in the cytoplasm. A member of DAP kinase family, DAPK2 has an N-terminal protein kinase domain, a conserved CAM binding domain and a 40A.A C-terminal tail required for homodimerization. Inactive DAPK2 is phosphorylated at conserved 'Ser-308', an inhibitory autophosphorylation site located within the CAM binding domain and is critical in inhibiting DAPK2 catalytic activation. Pro-apoptotic function of DAPK2 is activated by dephosphorylation, increase of intracellular Ca2+ levels, Ca2+ induced Calmodulin binding and homodimerization. Reports suggest DAPK2 along with DAPK1 induces membrane blebbing and formation of autophagic vesicles and plays a vital role in TGF-induced caspase-dependent Type-I and IFNa- induced caspase-independent autophagic type II cell death signaling. Northern Blot analysis detected abundant expression of DAPK2 mRNA in heart, lung and skeletal muscle.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: WB.

Showing Publication 1 - 1 of 1.

Publication using NB100-56344	Applications	Species
Chen CH, Huang PH, Chu PC et al. Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression J Biol Chem 2011-02-02 [PMID: 21282102] (WB) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB

Array NB100-56344

• DAP Kinase 2 Antibodies
• DAP Kinase 2 Proteins