Cytokeratin 17 Antibody

Among the members of the cytokeratin (CK) subfamily of intermediate filament (IF) proteins, CK 17 is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. It has an unusual expression pattern in normal and diseased states and has potential importance in tumor diagnosis. CK 17 synthesis seems to be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells" (1). It has been shown that CK 17 regulates cell growth through binding to the adaptor protein 14-3-3sigma. These findings reveal a new and unexpected role for the intermediate filament cytoskeleton in influencing cell growth and size by regulating protein synthesis (2). CK 17 is expressed in the nail bed, hair follicle, sebaceous glands, and other epidermal appendages (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	IF	Rat	05/18/2018	View Summary Application Immunofluorescence Sample Tested bladder cell line Species Rat Lot A115310 Comments Comments 1/200 dilution (would recommend higher in the future) with UROtsa rat urothelial cells. Secondary antibody of Goat Polyclonal Anti-Rabbit (Invitrogen) at 1/500 dilution.

Array NBP2-38536

• Cytokeratin 17 Antibodies
• Cytokeratin 17 ELISA Kit
• Cytokeratin 17 Lysate
• Cytokeratin 17 Proteins