Cytokeratin 17 Products

Description

Among the members of the cytokeratin (CK) subfamily of intermediate filament (IF) proteins, CK 17 is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. It has an unusual expression pattern in normal and diseased states and has potential importance in tumor diagnosis. CK 17 synthesis seems to be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells" (1). It has been shown that CK 17 regulates cell growth through binding to the adaptor protein 14-3-3sigma. These findings reveal a new and unexpected role for the intermediate filament cytoskeleton in influencing cell growth and size by regulating protein synthesis (2). CK 17 is expressed in the nail bed, hair follicle, sebaceous glands, and other epidermal appendages (3).

Bioinformatics

Entrez	16667 Mouse 287702 Rat 3872 Human
Uniprot	AAH00159 Human NP_000413.1 Human Q04695 Human
Product By Gene ID	3872
Alternate Names	39.1 CK-17 cytokeratin-17 Cytokeratin-17 K17 keratin 17 keratin, type I cytoskeletal 17 Keratin-17 keratin-17 PC PC2 PCHC1

Research Areas for Cytokeratin 17

Find related products by research area and learn more about each of the different research areas below.

Cancer