Cytokeratin 17 Antibody (RM351) Summary
Additional Information |
Recombinant Monoclonal Antibody |
Immunogen |
A peptide corresponding to residues in human Cytokeratin 17 (Uniprot # Q04695) |
Isotype |
IgG |
Clonality |
Monoclonal |
Host |
Rabbit |
Gene |
KRT17 |
Purity |
Protein A purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunohistochemistry 1:500-1:1000
- Western Blot 1:1000-1:20000
|
Packaging, Storage & Formulations
Storage |
Store at -20C. |
Buffer |
50% Glycerol/PBS, 1% BSA |
Preservative |
0.09% Sodium Azide |
Purity |
Protein A purified |
Alternate Names for Cytokeratin 17 Antibody (RM351)
Background
Among the members of the cytokeratin (CK) subfamily of intermediate filament (IF) proteins, CK 17 is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. It has an unusual expression pattern in normal and diseased states and has potential importance in tumor diagnosis. CK 17 synthesis seems to be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells" (1). It has been shown that CK 17 regulates cell growth through binding to the adaptor protein 14-3-3sigma. These findings reveal a new and unexpected role for the intermediate filament cytoskeleton in influencing cell growth and size by regulating protein synthesis (2). CK 17 is expressed in the nail bed, hair follicle, sebaceous glands, and other epidermal appendages (3).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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FAQs for Cytokeratin 17 Antibody (NBP3-18824) (0)
Secondary Antibodies
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