CYP46A1 Antibody

Cholesterol homeostasis in brain relies on a unique catabolic pathway which involves neuronal specific CYP46A1 (cytochrome P450 46A1) mediated conversion of cholesterol into 24(S)-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol, the most important mechanism of cholesterol turnover. While cholesterol cannot pass blood brain barrier (BBB), the major cholesterol elimination product from brain tissues is 24S-hydroxycholesterol which has the ability to pass BBB into circulation via ABCA1 (the origin of more than 90 % of plasma 24S-hydroxycholesterol). CYP46A1 belongs to cytochrome P450 family of enzymes and it localize to ER/microsomes as single-pass membrane protein, and unlike other cytochrome P450 sterol hydroxylases that are predominantly expressed in the liver, CYP46A1 is highly expressed in neurons of several brain regions as well as of neural retina. CYP46A1 is involved in memory and cognition through its effect on cerebral cholesterol turnover and a single nucleotide polymorphism T/C (rs754203) in intron 2 of CYP46A1 has been discovered as responsible for increased susceptibility to Alzheimer's disease.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: ICC/IF, IF/IHC, WB.

Showing Publications 1 - 2 of 2.

Publications using NB400-140	Applications	Species
Zhang J, Zhang F, Wu J et al. Glutamate affects cholesterol homeostasis within the brain via the up-regulation of CYP46A1 and ApoE Toxicology 2020-01-22 [PMID: 31981724] (WB, Human)	WB	Human
Brown III, J et al. Differential Expression of Cholesterol Hydroxylase in Alzheimer's Disease. The Journal of Biological Chemistry 279(33): 34674-34681. 2004-01-01 [PMID: 15148325] (ICC/IF, WB, IF/IHC, Human)	ICC/IF, WB, IF/IHC	Human

Array NB400-140

• CYP46A1 Antibodies
• CYP46A1 Lysate
• CYP46A1 Protein