CXCL10/IP-10/CRG-2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The gene for CRG-2, a mouse homolog of human IP-10, was originally identified as an immediate early gene induced in response to macrophage activation. It has since been shown that CRG-2 mRNA is induced by alpha / beta / gamma -interferons and by lipopolysaccharide in macrophages, astrocytes and microglia. Human IP-10 was also shown to be expressed in activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes, and smooth muscle cells. Mouse CRG-2 cDNA encodes a 98 amino acid (aa) residue precursor protein with a 21 aa residue signal peptide that is cleaved to form the 77 aa residue secreted mature protein. Mature CRG-2 shares approximately 67% amino acid sequence identity with human IP-10. The amino acid sequence of CRG-2 identified the protein as a member of the chemokine alpha subfamily that lacks the ELR domain. CRG-2 has been shown to be a chemoattractant for activated T-lymphocytes. Recently, human IP-10 has also been reported to be a potent inhibitor of angiogenesis and to display a potent thymus-dependent anti-tumor effect. A chemokine receptor specific for IP-10 and MIG (CXCR3) has been cloned and shown to be highly expressed in IL-2-activated T-lymphocytes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 10 applications: Flow Cytometry, Functional Assay, ICC, IHC, IHC-Fr, IHC-P, Immunohistochemistry, Neutralization, Tissue Culture, Western Blot.

Showing Publications 1 - 10 of 43. Show All 43 Publications. Collapse Publications.

Publications using AF-466-NA	Applications	Species
Chae, S;Lee, HJ;Lee, HE;Kim, J;Jeong, YJ;Lin, Y;Kim, HY;Leriche, G;Ehrlich, RS;Lingl, SC;Seo, MD;Lee, YH;Yang, J;Kim, JI;Hoe, HS; The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and rescues synaptic/cognitive functions by modulating DRD1 signaling or directly binding to Abeta Journal of neuroinflammation 2024-08-11 [PMID: 39129007] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
A Licht-Mura, SM Meadows, F Palaguachi, SC Song, S Jackvony, Y Bram, C Zhou, RE Schwartz, RC Froemke, AL Orr, AG Orr Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines Science Advances, 2023-04-19;9(16):eade1282. 2023-04-19 [PMID: 37075107] (IHC, Mouse)	IHC	Mouse
S Wang, Y Kuai, S Lin, L Li, Q Gu, X Zhang, X Li, Y He, S Chen, X Xia, Z Ruan, C Lin, Y Ding, Q Zhang, C Qi, J Li, X He, JL Pathak, W Zhou, S Liu, L Wang, L Zheng NF-kappaB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer Bmc Medicine, 2023-03-29;21(1):115. 3/29/2023 [PMID: 36978108]
Melanie Haffner-Luntzer, Birte Weber, Kazuhito Morioka, Ina Lackner, Verena Fischer, Chelsea Bahney et al. Altered early immune response after fracture and traumatic brain injury Frontiers in Immunology 2023-01-25 [PMID: 36761764]
Jasmin Maria Bülow, Nikolai Renz, Melanie Haffner-Luntzer, Verena Fischer, Astrid Schoppa, Jan Tuckermann et al. Complement receptor C5aR1 on osteoblasts regulates osteoclastogenesis in experimental postmenopausal osteoporosis Front Endocrinol (Lausanne) 2022-09-30 [PMID: 36246887]
Agnieszka Chryplewicz, Julie Scotton, Mélanie Tichet, Anoek Zomer, Ksenya Shchors, Johanna A. Joyce et al. Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity Cancer Cell 2022-10-10 [PMID: 36113478]
Perdigoto AL, Deng S, Du KC et al. Immune cells and their inflammatory mediators modify beta cells and cause checkpoint inhibitor-induced diabetes JCI insight 8/4/2022 [PMID: 35925682]
N Igarashi, K Miyata, TM Loo, M Chiba, A Hanyu, M Nishio, H Kawasaki, H Zheng, S Toyokuni, S Kon, K Moriyama, Y Fujita, A Takahashi Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells Oncogene, 2022-07-18;13(1):4157. 2022-07-18 [PMID: 35851277] (IHC, Mouse)	IHC	Mouse
Z Liang, P He, Y Han, CC Yun Survival of stem cells and progenitors in the intestine is regulated by LPA5-dependent signaling Cellular and Molecular Gastroenterology and Hepatology, 2022-04-04;0(0):. 2022-04-04 [PMID: 35390517] (Tissue Culture, Mouse)	Tissue Culture	Mouse
Jie X, Chen Y, Zhao Y et al. Targeting KDM4C enhances CD8+ T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer Journal for immunotherapy of cancer 2/1/2022 [PMID: 35121645]
K Somebang, J Rudolph, I Imhof, L Li, EC Niemi, J Shigenaga, H Tran, TM Gill, I Lo, BA Zabel, G Schmajuk, BT Wipke, S Gyoneva, L Jandreski, M Craft, G Benedetto, ED Plowey, I Charo, J Campbell, CJ Ye, SS Panter, MC Nakamura, W Eckalbar, CL Hsieh CCR2 deficiency alters activation of microglia subsets in traumatic brain injury Cell Reports, 2021-09-21;36(12):109727. 2021-09-21 [PMID: 34551293] (IHC, Mouse)	IHC	Mouse
N Javeed, TK Her, MR Brown, P Vanderboom, K Rakshit, AM Egan, A Vella, I Lanza, AV Matveyenko Pro-inflammatory beta cell small extracellular vesicles induce beta cell failure through activation of the CXCL10/CXCR3 axis in diabetes Cell Reports, 2021-08-24;36(8):109613. 2021-08-24 [PMID: 34433033] (Neutralization, Mouse)	Neutralization	Mouse
J Wang, Y Zhang, Y Xiao, X Yuan, P Li, X Wang, Y Duan, VL Seewaldt, D Yu Boosting immune surveillance by low-dose PI3K inhibitor facilitates early intervention of breast cancer American journal of cancer research, 2021-05-15;11(5):2005-2024. 2021-05-15 [PMID: 34094666] (Neutralization, Mouse)	Neutralization	Mouse
Ian H. Guldner, Qingfei Wang, Lin Yang, Samantha M. Golomb, Zhuo Zhao, Jacqueline A. Lopez et al. CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10 Cell 11/1/2020 [PMID: 33113353]
G Sorrentino, S Rezakhani, E Yildiz, S Nuciforo, MH Heim, MP Lutolf, K Schoonjans Mechano-modulatory synthetic niches for liver organoid derivation Nat Commun, 2020-07-10;11(1):3416. 7/10/2020 [PMID: 32651372]
McKinsey GL, Lizama CO, Keown-Lang AE et al. A new genetic strategy for targeting microglia in development and disease Elife 6/23/2020 [PMID: 32573436]
YJ Chen, CY Tsai, YM Cheng, SW Nieh, TK Yeh, CP Chen, MH Wang, LH Chou, TY Chiu, L Liu, C Ho, CT Chen, TW Liu Impacts of Intralipid on Nanodrug Abraxane Therapy and on the Innate Immune System Sci Rep, 2020-02-18;10(1):2838. 2020-02-18 [PMID: 32071352] (IHC, Mouse)	IHC	Mouse
L Li, MW Shirkey, T Zhang, Y Xiong, W Piao, V Saxena, C Paluskievi, YS Lee, N Toney, BM Cerel, Q Li, T Simon, KD Smith, KL Hippen, BR Blazar, R Abdi, JS Bromberg The lymph node stromal laminin alpha 5 shapes alloimmunity J. Clin. Invest., 2020-05-01;0(0):. 2020-05-01 [PMID: 32017712] (IHC, Mouse)	IHC	Mouse
S Trittel, BJ Chambers, U Heise, CA Guzmán, P Riese Key features and homing properties of NK cells in the liver are shaped by activated iNKT cells Sci Rep, 2019-11-08;9(1):16362. 2019-11-08 [PMID: 31704965] (Western Blot, Mouse)	Western Blot	Mouse
Jinfeng Zang, Jun Ye, Chi Zhang, Min Sha, Junye Gao Senescent hepatocytes enhance natural killer cell activity via the CXCL‑10/CXCR3 axis Experimental and Therapeutic Medicine 2019-09-23 [PMID: 31616512]
M Chen, RR Reed, AP Lane Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense Cell Stem Cell, 2019-09-12;25(4):501-513.e5. 2019-09-12 [PMID: 31523027] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Mudan Zhang, Xu Deng, Xinmeng Guan, Lanlan Geng, Ming Fu, Binman Zhang et al. Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4+ T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4 Frontiers in Immunology 2018-12-19 [PMID: 30619292]
S Hiyari, E Green, C Pan, S Lari, M Davar, R Davis, PM Camargo, S Tetradis, AJ Lusis, FQ Pirih Genome-Wide Association Study Identifies Cxcl Family Members as Partial Mediators of LPS-induced Periodontitis J. Bone Miner. Res., 2018-05-22;0(0):. 2018-05-22 [PMID: 29637625] (IHC-P, Mouse)	IHC-P	Mouse
M Muramatsu, L Gao, J Peresie, B Balderman, S Akakura, IH Gelman SSeCKS/AKAP12 scaffolding functions suppress B16F10-induced peritoneal metastasis by attenuating CXCL9/10 secretion by resident fibroblasts Oncotarget, 2017-08-09;8(41):70281-70298. 2017-08-09 [PMID: 29050279] (Neutralization, Mouse)	Neutralization	Mouse
VE Thaney, AM O'Neill, MM Hoefer, R Maung, AB Sanchez, M Kaul IFN? Protects Neurons from Damage in a Murine Model of HIV-1 Associated Brain Injury Sci Rep, 2017-04-20;7(0):46514. 2017-04-20 [PMID: 28425451] (Neutralization, Mouse, Rat)	Neutralization	Mouse, Rat
X Li, QY Yao, HC Liu, QW Jin, BL Xu, SC Zhang, CT Tu Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease J. Cell. Mol. Med., 2017-04-05;0(0):. 2017-04-05 [PMID: 28378526] (IHC, Mouse)	IHC	Mouse
Bao-Chun Jiang, Li-Na He, Xiao-Bo Wu, Hui Shi, Wen-Wen Zhang, Zhi-Jun Zhang et al. Promoted Interaction of C/EBP alpha with Demethylated Cxcr3 Gene Promoter Contributes to Neuropathic Pain in Mice The Journal of Neuroscience 2017-01-18 [PMID: 28100749]
Brain inflammation is accompanied by peripheral inflammation in Cstb (-/-) mice, a model for progressive myoclonus epilepsy J Neuroinflammation, 2016-11-28;13(1):298. 2016-11-28 [PMID: 27894304] (IHC-Fr, Mouse)	IHC-Fr	Mouse
CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata J Immunol, 2016-07-13;0(0):. 2016-07-13 [PMID: 27412416] (Flow Cytometry, IHC-P, Mouse)	Flow Cytometry, IHC-P	Mouse
Wightman S, Uppal A, Pitroda S, Ganai S, Burnette B, Stack M, Oshima G, Khan S, Huang X, Posner M, Weichselbaum R, Khodarev N Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome. Br J Cancer, 2015-06-04;113(2):327-35. 6/4/2015 [PMID: 26042934]
Terry G. Coursey, Ritu Bohat, Flavia L. Barbosa, Stephen C. Pflugfelder, Cintia S. de Paiva Desiccating Stress–Induced Chemokine Expression in the Epithelium Is Dependent on Upregulation of NKG2D/RAE-1 and Release of IFN-gamma in Experimental Dry Eye The Journal of Immunology 2014-11-15 [PMID: 25288568]
Mills Ko E, Ma J, Guo F, Miers L, Lee E, Bannerman P, Burns T, Ko D, Sohn J, Soulika A, Pleasure D Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model. J Neuroinflammation, 2014-06-12;11(0):105. 2014-06-12 [PMID: 24924222] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Zeng X, Nagavalli A, Smith C, Howard J, Su M Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency. J Immunol, 2013-03-13;190(8):3895-904. 2013-03-13 [PMID: 23487421] (IHC, Mouse)	IHC	Mouse
Timothy W. Phares, Stephen A. Stohlman, David R. Hinton, Cornelia C. Bergmann Astrocyte-Derived CXCL10 Drives Accumulation of Antibody-Secreting Cells in the Central Nervous System during Viral Encephalomyelitis Journal of Virology 2013-03-15 [PMID: 23302888]
Leconet W, Petit P, Peraldi-Roux S, Bresson D Nonviral delivery of small interfering RNA into pancreas-associated immune cells prevents autoimmune diabetes. Mol Ther, 2012-09-18;20(12):2315-25. 2012-09-18 [PMID: 22990670] (Western Blot, Mouse)	Western Blot	Mouse
Chang-Hyun Song, Osamu Honmou, Hidefumi Furuoka, Motohiro Horiuchi Identification of Chemoattractive Factors Involved in the Migration of Bone Marrow-Derived Mesenchymal Stem Cells to Brain Lesions Caused by Prions Journal of Virology 2011-11-01 [PMID: 21813601]
Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D Comprehensive assessment of chemokine expression profiles by flow cytometry. J. Clin. Invest., 2010-02-08;120(3):907-23. 2010-02-08 [PMID: 20197626] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
King VL, Lin AY, Kristo F, Anderson TJ, Ahluwalia N, Hardy GJ, Owens AP, Howatt DA, Shen D, Tager AM, Luster AD, Daugherty A, Gerszten RE Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture. Circulation, 2009-01-12;119(3):426-35. 2009-01-12 [PMID: 19139386] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Zhao Z, Burkly LC, Campbell S, Schwartz N, Molano A, Choudhury A, Eisenberg RA, Michaelson JS, Putterman C TWEAK/Fn14 interactions are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host model of systemic lupus erythematosus. J. Immunol., 2007-12-01;179(11):7949-58. 2007-12-01 [PMID: 18025243] (IHC-P, Mouse)	IHC-P	Mouse
Maeno T, Houghton AM, Quintero PA, Grumelli S, Owen CA, Shapiro SD CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J. Immunol., 2007-06-15;178(12):8090-6. 2007-06-15 [PMID: 17548647] (ICC, Mouse)	ICC	Mouse
Fujita H, Asahina A, Komine M, Tamaki K The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells. Cell. Immunol., 2007-05-15;245(2):70-9. 2007-05-15 [PMID: 17507001] (Functional Assay, Mouse)	Functional Assay	Mouse
Bitko V, Musiyenko A, Barik S Viral infection of the lungs through the eye. J. Virol., 2006-10-18;81(2):783-90. 2006-10-18 [PMID: 17050596] (Western Blot, Mouse)	Western Blot	Mouse
Cardona AE, Gonzalez PA, Teale JM CC chemokines mediate leukocyte trafficking into the central nervous system during murine neurocysticercosis: role of gamma delta T cells in amplification of the host immune response. Infect. Immun., 2003-05-01;71(5):2634-42. 2003-05-01 [PMID: 12704138] (ICC, Mouse)	ICC	Mouse
Show All 43 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	IHC-Fr	Mouse	12/05/2022	View Summary Application Immunohistochemistry-Frozen Sample Tested Mouse Spleen Species Mouse Lot AHC0721081

Array AF-466-NA

• CXCL10/IP-10/CRG-2 Antibodies
• CXCL10/IP-10/CRG-2 Antibody Pair
• CXCL10/IP-10/CRG-2 ELISA Kits
• CXCL10/IP-10/CRG-2 Lysate
• CXCL10/IP-10/CRG-2 Proteins
• CXCL10/IP-10/CRG-2 Proteins and Enzymes
• CXCL10/IP-10/CRG-2 ELISAs