CtIP Antibody (19E8)

CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disruppted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Chemotaxis, IP, WB.

Showing Publications 1 - 3 of 3.

Publications using NBP1-41205	Applications	Species
Liao CC, Tsai CY, Chang WC et al. RB-E2F1 complex mediates DNA damage responses through transcriptional regulation of ZBRk1. J Biol Chem 2010-10-01 [PMID: 20713352] (Chemotaxis, IP, WB, Mouse, Human)	Chemotaxis, IP, WB	Mouse, Human
Wu M, Soler DR, Abba MC et al. CtIP silencing as a novel mechanism of tamoxifen resistance in breast cancer. Mol Cancer Res 2007-12-01 [PMID: 18171986] (WB, Chemotaxis, IP, Mouse, Human)	WB, Chemotaxis, IP	Mouse, Human
Liu F, Lee WH. CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression. Mol Cell Biol 2006-04-01 [PMID: 16581787] (Chemotaxis, WB, IP, Mouse, Human)	Chemotaxis, WB, IP	Mouse, Human

Array NBP1-41205

• CtIP Antibodies
• CtIP Proteins