CHRND Antibody (88B)

Acetylcholine receptors (AChRs) mediate synaptic transmission at the neuromuscular junction. The channel-linked AChR that mediates rapid, excitatory actions of acetylcholine is called nicotinic AChR (nAChR) because it can be activated by nicotine. The non-channel linked AChR that medicates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine. The nAChRs fall into two subclasses, the muscle-type and the neuronal-type. The muscle-type receptor is a pentameric glycoprotein of five membrane spanning subunits, (2 alpha 1's, beta 1, gamma or epsilon and delta) which form a ligand gated ion channel. The neuronal nAChR is also a pentamer, but unlike the muscle-type, is made up of only two general types of subunits, alpha and beta of which multiple subtypes have been described (alpha 2 to alpha 8 and beta 2 to beta 4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: WB.

Showing Publications 1 - 4 of 4.

Publications using NB120-2804	Applications	Species
Li B, Chen L, Gu Yd Stability of motor endplates is greater in the biceps than in the interossei in a rat model of obstetric brachial plexus palsy Neural Regen Res 2020-09-01 [PMID: 32209772] (WB, Rat)	WB	Rat
Dmytrenko GM, Pumplin DW, Bloch RJ. Dystrophin in a membrane skeletal network: localization and comparison to other proteins. J Neurosci;13(2):547-58. 1993-02-01 [PMID: 8426227]
Bloch RJ, Sealock R, Pumplin DW, Luther PW, Froehner SC. Association of acetylcholine receptors with peripheral membrane proteins: evidence from antibody-induced coaggregation. J Membr Biol;138(1):13-28. 1994-02-01 [PMID: 8189428]
Froehner SC, Douville K, Klink S, Culp WJ. Monoclonal antibodies to cytoplasmic domains of the acetylcholine receptor. J Biol Chem;258(11):7112-20. 1983-06-10 [PMID: 6189834]

Array NB120-2804

• CHRND Antibodies
• CHRND Lysate
• CHRND Proteins