CHREBP Antibody (2D9NB) - BSA Free

Carbohydrate response element-binding protein (ChREBP) is a glucose sensitive basic helix-loop-helix/leucine zipper transcription factor which heterodimerise with MLX and binds to carbohydrate response element (ChoRE) on DNA for the induction genes involved in glycolysis, de novo lipogenesis (DNL), and fatty acid desaturation. Some of the target genes of ChREBP are glucokinase (GCK), fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), pyruvate kinase/liver type pyruvate kinase (PK1/ PKLR), delta-9-desaturase (SCD/SCD1) etc. ChREBP is expressed as alpha and beta alternatively spliced isoforms, and among these two isoforms, the alpha-isoform is activated in a glucose-dependent manner. ChREBP is expressed in the cytoplasm and nuclei of a number of mammalian tissues, with high levels found in liver, skeletal muscle, white/brown adipose, heart, kidney, cerebellum and intestine. Glucose stimulates ChREBP transcriptional expression and activates the transactivity of ChREBP protein. It is activated independent of insulin and recent findings have suggested that together with its binding partner Mlx, ChREBP implicates in metabolic processes, insulin signaling related pathways, and also tumorigenesis/cancers. Also, increased hepatic ChREBP expression has been suggested to result in development of non-alcoholic fatty liver disease (NAFLD) and obesity through the conversion of carbohydrates into triglycerides (de novo lipogenesis).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: Chemotaxis, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP2-44307	Applications	Species
Hu A, Lan H, Yao Z, Kong X. Carbohydrate response element‐binding protein ( C h REBP ) mediates decreased SNAP 25 expression in islets from diabetic Goto‐Kakizaki ( GK ) rats FEBS Open Bio 2024-09-19 [PMID: 39300600]
Song Z, Xiaoli AM, Li Y et al. The conserved Mediator subunit Cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation Molecular metabolism 2022-07-18 [PMID: 35863637] (WB, Mouse)	WB	Mouse
Ly NH, Maekawa T, Yoshida K et al. RNA-Sequencing Analysis of Paternal Low-Protein Diet-Induced Gene Expression Change in Mouse Offspring Adipocytes G3 (Bethesda) 2019-07-09 [PMID: 31289120] (Chemotaxis, Mouse)	Chemotaxis	Mouse
Kammoun H L, Chabanon H et al. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 2009-01-05 [PMID: 19363290] (WB, Rat)	WB	Rat
Butler J A, Hagen T M et al. Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion. Arch Biochem Biophys 2009-01-05 [PMID: 19232511] (WB, Rat)	WB	Rat

Array NBP2-44307

• CHREBP Antibodies
• CHREBP Lysate
• CHREBP Proteins