CDC7 Antibody - BSA Free

CDC7L1, CDC7 type protein kinase, regulates firing of the origins of initiation in DNA replication. CDC7L1 forms a complex with a Dbf4-related regulatory subunit to generate an active kinase. Mini-chromosome maintenance protein (MCM) is the major physiological target of Cdc7L1. At least three mRNA variants have been reported. Overexpression of the CDC7L1 protein may be associated with neoplastic transformation for some tumors. CDC7L1 has been documented in a wide range of tissues. One variant is expressed ubiquitously in human tissues while at least one other has been shown to be testis-specific. ESTs have been isolated from several tissue libraries, including normal embryo, gallbladder, lymph node and thymus and cancerous duodenum and embryo.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publication 1 - 1 of 1.

Publication using NLS7979	Applications	Species
Kitamura R, Fukatsu R, Kakusho N et al. Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition. J Biol Chem. 2011-07-01 [PMID: 21536671]

Images	Ratings	Applications	Species	Date	Details
Enlarge	1 reviewed by: Verified Customer	Simple Western	Human	08/27/2020	View Summary Application Simple Western Sample Tested HCT116 cell line lysate Species Human Lot 41361 Comments Comments 0.8mg/ml; HCT116 cell lysate ***Bio-Techne Response: This review was submitted through the legacy Novus Innovators Program, reflecting a new species or application tested on a primary antibody.***

Array NLS7979

• CDC7 Antibodies
• CDC7 Lysates
• CDC7 Protein