CD74 Antibody (PIN.1) - BSA Free

CD74, also known as the MHC class II associated invariant chain (Ii), is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is produced in molar excess over MHC class II and some of this is expressed by an unknown pathway on the cell surface independent of or in association with MHC class II molecules. The half life of CD74 on the cell surface is only 3 to 4 min after which it is internalized. It has been proposed that cell surface CD74 binds MHC class II molecules which have lost their antigenic peptide leading to internalization and reloading with antigenic peptide. The transport route of class II alpha/beta/Ii complexes is regulated selectively by two forms of CD74 (p33 and p35) which are generated by the use of alternative translation initiation sites. CD74 is expressed primarily by antigen presenting cells such as B lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages and monocytes together, with many epithelial cells. CD74 may exist in different isoforms ranging in size from 33 to 41kDa, depending on genetic splicing.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IHC, WB.

Showing Publications 1 - 6 of 6.

Publications using NB100-1985	Applications	Species
Weng Y, Lou J, Bao Y et al. Single-Cell RNA Sequencing Technology Revealed the Pivotal Role of Fibroblast Heterogeneity in Angiotensin II-Induced Abdominal Aortic Aneurysms DNA and cell biology 2022-04-22 [PMID: 35451888]
Koh YW, Han JH, Haam S, Lee HW. An immune-related gene expression signature predicts brain metastasis in lung adenocarcinoma patients after surgery: gene expression profile and immunohistochemical analyses Translational Lung Cancer Research 2021-03-15 [PMID: 33718023] (IHC)	IHC
Tanese K, Hashimoto Y, Berkova Z et al. Cell Surface CD74-MIF Interactions Drive Melanoma Survival in Response to Interferon-Gamma J. Invest. Dermatol. 2015-06-03 [PMID: 26039541] (WB, Human)	WB	Human
Katsel P, Tan W, Haroutunian V. Gain in brain immunity in the oldest-old differentiates cognitively normal from demented individuals. PLoS One 4(10):e7642. 2009-10-29 [PMID: 19865478]
Roche PA, Marks MS, Cresswell P. Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain. Nature. 1991-12-05 [PMID: 1956401]
Lamb CA, Cresswell P. Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexes. J Immunol. 1992-06-01 [PMID: 1588042]

Array NB100-1985

• CD74 Antibodies
• CD74 ELISA Kit
• CD74 Lysates
• CD74 Proteins
• CD74 Proteins and Enzyme