CD74 Products

Description

CD74, also known as the MHC class II associated invariant chain (Ii), is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is produced in molar excess over MHC class II and some of this is expressed by an unknown pathway on the cell surface independent of, or in association with, MHC class II molecules. The half life of CD74 on the cell surface is only 3 to 4 min after which it is internalized. It has been proposed that cell surface CD74 binds MHC class II molecules which have lost their antigenic peptide leading to internalization and reloading with antigenic peptide. The transport route of class II alpha/beta/Ii complexes is regulated selectively by two forms of CD74 (p33 and p35) which are generated by the use of alternative translation initiation sites. CD74 is expressed primarily by antigen presenting cells such as B lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages and monocytes together, with many epithelial cells. CD74 may exist in different isoforms ranging in size from 33 to 41 kDa, depending on genetic splicing.

Bioinformatics

Entrez	972 Human
Uniprot	AAH24272 Human NM_001025159 Human NP_001020329.1 Human NP_004346 Human P04233 Human
Product By Gene ID	972
Alternate Names	CD74 antigen (invariant polypeptide of major histocompatibility complex, classII antigen-associated) CD74 antigen CD74 molecule, major histocompatibility complex, class II invariant chain DHLAGgamma chain of class II antigens HLA class II histocompatibility antigen gamma chain HLADG HLA-DR antigens-associated invariant chain HLA-DR-gamma Ia antigen-associated invariant chain Ia-associated invariant chain Ia-GAMMA II Ii MHC HLA-DR gamma chain p33

Research Areas for CD74

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Immunology

Related CD74 Blog Posts

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CD74 - a central player in antigen presentation by MHC class II Cluster of differentiation 74 (CD74) is an important integral membrane protein that serves as a chaperone for MHC class II molecules. CD74, also known as the invariant chain or Ii, is needed for the proper folding and trafficking of MHC class II in...    Read more.

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