Human peripheral blood mononuclear cell (PBMCs) were stained with Rat Anti-Human/Mouse CD44 Alexa Fluor® 488-conjugated Monoclonal Antibody (Catalog # FAB6127G, filled histogram) or isotype control antibody ...read more
Mouse splenocytes were stained with Rat Anti-Human/Mouse CD44 Alexa Fluor® 488-conjugated Monoclonal Antibody (Catalog # FAB6127G, filled histogram) or isotype control antibody (Catalog # IC013G, open histogram). ...read more
12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide
Notes
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for CD44 Antibody (IM7.8.1R) [Alexa Fluor® 488]
CD44 antigen
CD44 molecule (Indian blood group)
CD44
CD44R
CDw44
cell surface glycoprotein CD44
chondroitin sulfate proteoglycan 8
CSPG8
ECMR-III
epican
Extracellular matrix receptor III
GP90 lymphocyte homing/adhesion receptor
HCAM
HCELL
hematopoietic cell E- and L-selectin ligand
Heparan sulfate proteoglycan
Hermes antigen
homing function and Indian blood group system
HUTCH-I
Hyaluronate receptor
IN
LHR
MC56
MDU2
MDU2CD44 antigen (homing function and Indian blood group system)
MDU3
MDU3CDW44
MIC4
MIC4MGC10468
MUTCH-I
Pgp1
PGP-1
PGP-I
Phagocytic glycoprotein 1
Phagocytic glycoprotein I
Background
CD44, also known as
ECMR-III, Hermes Antigen, Pgp1, Ly-24, GP90, and HUTCH-I, is a ubiquitously expressed
protein that is the major receptor for hyaluronic acid (HA). CD44 mediates cell-cell
and cell-matrix interaction through its affinity for HA, and possibly also through
its affinity for other ligands such as osteopontin, collagen, and matrix
metalloproteinases (MMPs). Adhesion with HA plays an important role in cell
migration, tumor growth and progression. In cancer cells, may play an important
role in invadopodia formation. Also involved in lymphocyte activation,
recirculation and homing, and in hematopoiesis. Mouse CD44 has a 22 amino acid (aa) signal
sequence, an extracellular domain (ECD) with a 100 aa hyaluronan-binding
disulfide-stabilized link region and a 48-463 aa stem region, a 21 aa
transmembrane domain, and a 72 aa cytoplasmic domain. CD44 exists as a large
number of different isoforms due to alternative RNA splicing. Clone IM7.8.1 has
been reported to recognize all isoforms of CD44. In the ECD, human and mouse CD44 share about 65% aa sequence identity.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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