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CD161/NK1.1 Antibody (694370) [DyLight 550]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, CyTOF-ready
Clone
694370
Clonality
Monoclonal
Host
Rat
Conjugate
DyLight 550

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB7614U-100UG
Alexa Fluor 405
FAB7614V-100UG
Alexa Fluor 488
FAB7614G
Alexa Fluor 532
FAB7614X
Alexa Fluor 594
FAB7614T-100UG
Alexa Fluor 647
FAB7614R-100UG
Alexa Fluor 700
FAB7614N-100UG
Alexa Fluor 750
FAB7614S-100UG
Allophycocyanin/Cy7
FAB7614APCCY7
Biotin
FAB7614B
CoraFluor 1
FAB7614CL1
DyLight 350
FAB7614D
DyLight 405
FAB7614E
DyLight 488
FAB7614K
DyLight 594
FAB7614M
DyLight 650
FAB7614W
DyLight 680
FAB7614Y
DyLight 755
FAB7614Z
FITC
FAB7614F
HRP
FAB7614H
Janelia Fluor 525
FAB7614JF525
Janelia Fluor 549
FAB7614I
Janelia Fluor 585
FAB7614JF585
Janelia Fluor 635
FAB7614JF635
Janelia Fluor 646
FAB7614J
Janelia Fluor 669
FAB7614JF669
PE/Atto594
FAB7614PEATT594
PE/Cy5.5
FAB7614PECY55
PE/Cy7
FAB7614PECY7
PerCP
FAB7614C
Unconjugated
FAB7614G
mFluor Violet 450 SE
FAB7614MFV450
mFluor Violet 500 SE
FAB7614MFV500
mFluor Violet 610 SE
FAB7614MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
FAB7614G
Carrier Free
MAB7614
Carrier Free
FAB7614G
Carrier Free
MAB7614-SP
Carrier Free
FAB7614V-100UG
Carrier Free
FAB7614U-100UG
Carrier Free
FAB7614T-100UG
Carrier Free
FAB7614S-100UG
Carrier Free
FAB7614R-100UG
Carrier Free
FAB7614N-100UG
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CD161/NK1.1 Antibody (694370) [DyLight 550] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse CD161/NK1.1
Val62-Ser220
Accession # P27814
Specificity
Detects mouse CD161/NK1.1 expressed specifically in the C57/B6 mouse strain. No detection of  CD161/NK1.1 was observed in the BALB/c mouse strain. In direct ELISAs, less than 5% cross-reactivity with recombinant mouse (rm) KLRB-1B is observed.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
KLRB1C
Purity
Protein A or G purified from hybridoma culture supernatant
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for CD161/NK1.1 Antibody (694370) [DyLight 550]

  • CD161 antigen
  • CD161
  • CD161/NK1.1
  • CD161c
  • CLEC5BC-type lectin domain family 5 member B
  • HNKR-P1a
  • killer cell lectin-like receptor subfamily B member 1
  • killer cell lectin-like receptor subfamily B, member 1
  • Klrb1c
  • Ly55c
  • Ly-59
  • Natural killer cell surface protein P1A
  • NKR-P1
  • NKR-P1AMGC138614
  • NKRP1ANKR

Background

NK-1.1 surface antigen is encoded by the NKR-P1B/NKR-P1C gene, also known as CD161b/CD161c and Ly-55. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN- gamma production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers. The PK136 antibody has been reported to deplete NK cells, induce redirected lysis, block NK cell function, and induce NK cell proliferation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol KLRB1C