CCL18/PARC Antibody [Biotin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCL18, also known as alternative macrophage activation-associated CC chemokine (AMAC)-1, macrophage inflammatory protein (MIP)-4, and dendritic cell chemokine (DC-CK1), is a novel CC chemokine that is highly homologous to MIP-1 alpha (61% amino acid (aa) sequence identity). CCL18 cDNA encodes an 89 aa residue precursor protein with a 20 aa putative signal peptide that is cleaved to generate a 69 aa residue mature protein which lacks potential glycosylation sites. In vitro, CCL18 mRNA expression is induced in alternatively activated macrophages by Th2 cytokines such as IL-4, IL-10, and IL-13, and inhibited by IFN‑ gamma . CCL18 mRNA is also expressed by GM-CSF/IL-4-induced monocyte-derived dendritic cells. In vivo, CCL18 is highly expressed in lung and placenta but is not expressed in epidermal Langerhans cells. Recombinant CCL18 has been shown to chemoattract naive T cells but not monocytes or neutrophils.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: Complex Application, ELISA Development (Detection), ICC, Luminex Development.

Showing Publications 1 - 6 of 6.

Publications using BAF394	Applications	Species
M Ossorio, V Martínez, MA Bajo, G Del Peso, MJ Castro, S Romero, R Selgas, T Bellón Prominent Levels of the Profibrotic Chemokine CCL18 during Peritonitis: In Vitro Downregulation by Vitamin D Receptor Agonists Biomed Res Int, 2018-04-04;2018(0):6415892. 2018-04-04 [PMID: 29850544] (ICC, Human)	ICC	Human
Per Kempe, Daniel Eklund, Agnes Hallin, Mats Hammar, Tomas Olsson, Jan Brynhildsen et al. Immune profile in relation to sex steroid cyclicity in healthy women and women with multiple sclerosis Journal of Reproductive Immunology 2018-04-01 [PMID: 29501895]
N Quillinan, KE Clark, B Youl, J Vernes, D McIntosh, S Haq, CP Denton Multiplex serum protein analysis reveals potential mechanisms and markers of response to hyperimmune caprine serum in systemic sclerosis Arthritis Res. Ther, 2017-03-07;19(1):45. 2017-03-07 [PMID: 28270187] (ELISA Development (Detection), Human)	ELISA Development (Detection)	Human
T. R. Abrahamsson, M. Sandberg Abelius, A. Forsberg, B. Björkstén, M. C. Jenmalm A Th1/Th2-associated chemokine imbalance during infancy in children developing eczema, wheeze and sensitization Clinical & Experimental Allergy 2011-12-01 [PMID: 21801246]
Deegan PB, Pavlova E, Tindall J Osseous manifestations of adult Gaucher disease in the era of enzyme replacement therapy. Medicine (Baltimore), 2011-01-01;90(1):52-60. 2011-01-01 [PMID: 21200186] (Complex Application, Human)	Complex Application	Human
Pavlova EV, Deegan PB, Tindall J, McFarlane I, Mehta A, Hughes D, Wraith JE, Cox TM Potential biomarkers of osteonecrosis in Gaucher disease. Blood Cells Mol. Dis., 2010-11-13;46(1):27-33. 2010-11-13 [PMID: 21075651] (Luminex Development, Human)	Luminex Development	Human

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	ELISA	Human	01/14/2015	View Summary Application ELISA Sample Tested See PMID: 19120345 Species Human
	4 reviewed by: Verified Customer	ELISA	Human	01/14/2015	View Summary Application ELISA Sample Tested See PMID: 21801246 Species Human
	4 reviewed by: Verified Customer	ELISA	Human	01/14/2015	View Summary Application ELISA Sample Tested See PMID: 19175890 Species Human
	4 reviewed by: Verified Customer	ELISA	Human	01/13/2015	View Summary Application ELISA Sample Tested See PMID 22280057 Species Human

Array BAF394

• CCL18/PARC Antibodies
• CCL18/PARC Lysate
• CCL18/PARC Protein
• CCL18/PARC Proteins and Enzymes
• CCL18/PARC ELISAs