Caveolin-1 Antibody (7C8)

Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Drosophila melanogaster, Sheep.

We have publications tested in 9 applications: FLOW, IB, ICC/IF, IF/IHC, IHC, IHC-Fr, IHC-P, IP, WB.

Showing Publications 1 - 10 of 37. Show All 37 Publications. Collapse Publications.

Publications using NB100-615	Applications	Species
Zhu A, Lin Y, Hu X et al. Treadmill exercise decreases cerebral edema in rats with local cerebral infarction by modulating AQP4 polar expression through the caveolin-1/TRPV4 signaling pathway Brain research bulletin 2022-10-01 [PMID: 35961528] (IHC-Fr, Rat)	IHC-Fr	Rat
Yokomori H, Inagaki Y, Ando W, Hara M. Spatiotemporal expression of matrix metalloproteinase-1 in progression of nonalcoholic steatohepatitis. Journal of Modern Human Pathology. 2016-03-30 (IHC-P, Human)	IHC-P	Human
Margaret JV Deciphering the Role of Caveolae in Human Meniscus Fibrochondrocytes Thesis 2022-01-01 (ICC/IF, Human)	ICC/IF	Human
Dalton CM, Schlegel C, Hunter CJ Caveolin-1: A Review of Intracellular Functions, Tissue-Specific Roles, and Epithelial Tight Junction Regulation Biology 2023-11-05 [PMID: 37998001] (IHC)	IHC
Wang S, Ichinomiya T, Savchenko P Et al. Subpial delivery of adeno-associated virus 9-synapsin-caveolin-1 (AAV9-SynCav1) preserves motor neuron and neuromuscular junction morphology, motor function, delays disease onset, and extends survival in hSOD1(G93A) mice Theranostics 2022-08-01 [PMID: 35910808] (IF/IHC, Mouse) Details: Citation using the Alexa Fluor 594 version of this antibody.	IF/IHC	Mouse
Wang J, Xu J, Zang G et al. trans-2-Enoyl-CoA Reductase Tecr-Driven Lipid Metabolism in Endothelial Cells Protects against Transcytosis to Maintain Blood-Brain Barrier Homeostasis Research (Washington, D.C.) 2022-04-04 [PMID: 35465346] (WB, Human)	WB	Human
Sanchez-Solana B, Wang D, Qian X Et al. The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1 Molecular cancer 2021-11-02 [PMID: 34727930]
Collins DP, Osborn MJ, Steer CJ. et al. Differentiation of immortalized human multi-lineage progenitor to alveolar type 2-like cells: angiotensin-converting enzyme 2 expression and binding of severe acute respiratory syndrome coronavirus 2 spike and spike 1 proteins Cytotherapy 2021-08-01 [PMID: 34551876] (ICC/IF, Human)	ICC/IF	Human
Kurebayashi Y, Bajimaya S, Watanabe M et al. Human parainfluenza virus type 1 regulates cholesterol biosynthesis and establishes quiescent infection in human airway cells PLOS Pathogens 2021-09-16 [PMID: 34529742] (WB, Human)	WB	Human
Anderson-Baucum E, PiNeros AR, Kulkarni A et al. Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype Cell metabolism 2021-09-07 [PMID: 34496231] (IHC-P, Mouse)	IHC-P	Mouse
Daneva Z, Ottolini M, Chen YL et al. Endothelial pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure in mice eLife 2021-09-07 [PMID: 34490843]
Jiang H, Wu T, Liu J, et al. Caveolae/rafts protect human cerebral microvascular endothelial cells from Streptococcus suis serotype 2 alpha -enolase-mediated injury Veterinary microbiology 2021-01-06 [PMID: 33445055] (ICC/IF, Human)	ICC/IF	Human
Srisomboon Y, Squillace DL, Maniak PJ et al. Fungal allergen-induced IL-33 secretion involves cholesterol-dependent, VDAC-1-mediated ATP release from the airway epithelium J. Physiol. (Lond.) 2020-02-27 [PMID: 32103508] (ICC/IF, Human)	ICC/IF	Human
Savio, L E B, de Andrade Mello, P Et al. P2X7 receptor activation increases expression of caveolin-1 and formation of macrophage lipid rafts, thereby boosting CD39 activity. J Cell Sci 2020-03-06 [PMID: 32005701] (IF/IHC, Drosophila melanogaster)	IF/IHC	Drosophila melanogaster
Kim SA, Kim SJ, Choi YA et al. Retinal VEGFA maintains the ultrastructure and function of choriocapillaris by preserving the endothelial PLVAP Biochem. Biophys. Res. Commun. 2019-11-20 [PMID: 31759628] (IB, Mouse, Human)	IB	Mouse, Human
de Andrade Mello P, Bian S, Savio LEB et al. Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death Oncotarget. 2017-09-14 [PMID: 28978031] (IP, WB, Mouse)	IP, WB	Mouse
Mello PA, Bian S, Baggio Savio LE, et al. Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death Oncotarget 2017-06-21 [PMID: 28658673] (IP, Human)	IP	Human
Liu C, Liu T, Yu X et al. A preliminary study on the interaction between Asn-Gly-Arg (NGR)-modified multifunctional nanoparticles and vascular epithelial cells Acta Pharm Sin B. 2017-04-01 [PMID: 28540174] (FLOW, ICC/IF, Human) Details: Citation used the DyLight 488 format of this antibody.	FLOW, ICC/IF	Human
Eliyatkin N, Aktas S, Diniz G et al. Expression of Stromal Caveolin- 1 May Be a Predictor for Aggressive Behaviour of Breast Cancer. Pathol. Oncol. Res. 2017-02-24 [PMID: 28236153]
Arima Mitsuru, Cui Dan, Kimura Tokuhiro et al. Basigin can be a therapeutic target to restore the retinal vascular barrier function in the mouse model of diabetic retinopathy. Scientific Reports 2016-01-01 [PMID: 27917946] (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse
Ayaz D, Diniz G, Kahraman DS et al. The evaluation of the caveolin-1 and AT-rich interactive domain 1 alpha expressions in uterine smooth muscle tumors. Indian J Pathol Microbiol. 2016-08-11 [PMID: 27510664] (IF/IHC)	IF/IHC
Li Z, Scott MJ, Fan EK et al. Tissue damage negatively regulates LPS-induced macrophage necroptosis Cell Death Differ. 2016-09-01 [PMID: 26943325] (WB, ICC/IF, Mouse) Details: Citation used the Alexa Fluor 488 format of this antibody.	WB, ICC/IF	Mouse
Francesca G, Cinzia P, Antonella B et al. SMN affects membrane remodelling and anchoring of the protein synthesis machinery. J. Cell. Sci. 2016-01-07 [PMID: 26743087] (ICC/IF, Human)	ICC/IF	Human
Boyce AK, Kim MS, Wicki-Stordeur LE, Swayne LA et al. ATP stimulates Pannexin 1 internalisation to endosomal compartments Biochem. J. 2015-07-20 [PMID: 26195825] (ICC/IF, Mouse)	ICC/IF	Mouse
Yokomori H, Ando W, Yoshimura K et al. Increases in endothelial caveolin-1 and cavins correlate with cirrhosis progression Micron 2015-06-19 [PMID: 26086560] (Human)		Human
Kallenborn-Gerhardt W, Lu R, Bothe A et al. Phosphodiesterase 2A Localized in the Spinal Cord Contributes to Inflammatory Pain Processing. Anesthesiology 2014-04-22 [PMID: 24758774] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Czeredys M, Samluk L, Michalec K et al. Caveolin-1 - A Novel Interacting Partner of Organic Cation/Carnitine Transporter (Octn2): Effect of Protein Kinase C on This Interaction in Rat Astrocytes. PLoS One 2013-12-13 [PMID: 24349196] (WB, Rat)	WB	Rat
Bielaszewska M, Ruter C, Kunsmann L et al. Enterohemorrhagic Escherichia coli Hemolysin Employs Outer Membrane Vesicles to Target Mitochondria and Cause Endothelial and Epithelial Apoptosis. PLoS Pathog 2013-12-01 [PMID: 24348251] (ICC/IF, Human)	ICC/IF	Human
Diaz-Ruiz A, Rabanal-Ruiz Y, Travez A et al. The Long Coiled-Coil Protein NECC2 Is Associated to Caveolae and MODULATES NGF/TrkA Signaling IN PC12 CELLS. PLoS One. 2013-09-12 [PMID: 24069119] (WB, ICC/IF, Rat)	WB, ICC/IF	Rat
Charfi C, Levros LC Jr, Edouard E, Rassart E. Characterization and identification of PARM-1 as a new potential oncogene. Mol Cancer 2013-07-31 [PMID: 23902727] (ICC/IF, Mouse)	ICC/IF	Mouse
Grenon SM, Jeanne M, Aguado-Zuniga J et al. Effects of Gravitational Mechanical Unloading in Endothelial Cells: Association between Caveolins, Inflammation and Adhesion Molecules Sci Rep 2013-03-20 [PMID: 23511048] (ICC/IF, Human)	ICC/IF	Human
Teng RJ, Du J, Afolayan AJ et al. AMP Kinase Activation Improves Angiogenesis in Pulmonary Artery Endothelial Cells with In Utero Pulmonary Hypertension Am J Physiol Lung Cell Mol Physiol 2012-10-26 [PMID: 23103561] (WB, Sheep)	WB	Sheep
Munjal, C, Tyagi, N, Lominadze, D,Tyagi, S C. Matrix metalloproteinase-9 in homocysteine-induced intestinal microvascular endothelial paracellular and transcellular permeability J. Cell. Biochem 2012-01-01 [PMID: 22275073]
Rudnick JA, Arendt LM, Klebba I et al. Functional Heterogeneity of Breast Fibroblasts Is Defined by a Prostaglandin Secretory Phenotype that Promotes Expansion of Cancer-Stem Like Cells. PLoS ONE;6(9). 2011-01-01 [PMID: 21957456]
Davalos A, Fernandez-Hernando C, Sowa G et al. Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells. Mol Cell Proteomics 2010-10-01 [PMID: 20585024]
Catalucci D, Zhang D-H, DeSantiago J et al. Akt regulates L-type Ca2+ channel activity by modulating Cav{alpha}1 protein stability. J Cell Biol;184(6):923-933. 2009-01-01 [PMID: 19307602] (WB, Mouse)	WB	Mouse
Souto RP, Vallega G, Wharton J et al. Immunopurification and characterization of rat adipocyte caveolae suggest their dissociation from insulin signaling. J Biol Chem;278(20):18321-9. 2003-05-16 [PMID: 12637562]
Show All 37 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: auriane ernault	IHC-Fr	Human	03/05/2021	View Summary Application Immunohistochemistry-Frozen Sample Tested Adipose tissue Species Human Lot b Comments Comments Antibody dilution 1:250
Enlarge	5 reviewed by: Verified Customer	ICC	Human	08/12/2015	View Summary Application Immunocytochemistry Sample Tested Human prostate cancer cell line Species Human Lot b
	5 reviewed by: Verified Customer	IF	Human	12/19/2014	View Summary Application Immunofluorescence Sample Tested See PMID: 24348251 Species Human

Array NB100-615

• Caveolin-1 Antibodies
• Caveolin-1 ELISA Kits
• Caveolin-1 Lysate
• Caveolin-1 Proteins