Cav3.2 Antibody (S55/10)

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, Cav3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (3, 4). Studies also suggest that the up-regulations of Cav3.2 may participate in the progression of prostate cancer toward an androgen-independent stage (5).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 3 applications: ICC/IF, IP, WB.

Showing Publications 1 - 9 of 9.

Publications using NBP1-22444	Applications	Species
Zhang Y, Qian Z, Jiang D Et al. Neuromedin B receptor stimulation of Cav3.2 T-type Ca2+ channels in primary sensory neurons mediates peripheral pain hypersensitivity Theranostics 2021-09-09 [PMID: 34646374] (WB, Mouse)	WB	Mouse
Gandini MA, Souza IA, Khullar A Et al. Regulation of CaV3.2 channels by the receptor for activated C kinase 1 (Rack-1) Pflugers Archiv : European journal of physiology 2021-10-08 [PMID: 34623515] (WB)	WB
Fan G, Kamann M, Cui Y et Al. Age attenuates the T-type CaV 3.2-RyR axis in vascular smooth muscle Aging Cell 2020-03-18 [PMID: 32187825] (WB, Mouse)	WB	Mouse
Wang H, Wei Y, Pu Y et al. Brain-derived neurotrophic factor stimulation of T-type Ca2+ channels in sensory neurons contributes to increased peripheral pain sensitivity Sci Signal 2019-09-24 [PMID: 31551295] (WB, Rat)	WB	Rat
Garcia-Caballero A, Gandini MA, Huang S et al. Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC Mol Brain 2019-02-08 [PMID: 30736831] (WB, Mouse)	WB	Mouse
Hashad AM, Harraz OF, Brett SE. Caveolae Link CaV3.2 Channels to BKCa-Mediated Feedback in Vascular Smooth Muscle Vascular Biology [PMID: 30354206] (WB)	WB
Garcia-Caballero A, Zhang FX, Hodgkinson V et al. T-type calcium channels functionally interact with spectrin (a/B) and ankyrin B Mol Brain 2018-05-02 [PMID: 29720258] (ICC/IF)	ICC/IF
Stemkowski P, Garcia-Caballero A, Gadotti VM et al. TRPV1 Nociceptor Activity Initiates USP5/T-type Channel-Mediated Plasticity. Cell Rep. 2016-12-13 [PMID: 27974205] (Mouse)		Mouse
Garcia-Caballero A, Gadotti VM, Stemkowski P et al. The Deubiquitinating Enzyme USP5 Modulates Neuropathic and Inflammatory Pain by Enhancing Cav3.2 Channel Activity. Neuron. 2014-09-03 [PMID: 25189210] (WB, IP, Mouse)	WB, IP	Mouse

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	WB	Other	05/13/2014	View Summary Application Western Blot Sample Tested HEK293 whole cell lysate Species Other Lot 0907

Array NBP1-22444

• Cav3.2 Antibodies
• Cav3.2 Protein