Calcium-sensing R/CaSR Antibody (HL 1499) - BSA Free

Calcium Sensing Receptor (CaSR) was the first GPCR identified whose main physiological ligand is an ion and it has the ability to sense extracellular concentration of Ca2+. CaSR's activity is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and it is capable of interaction with VCP, RNF19A (execute CASR's ubiquitination) and ARRB1. CaSR is expressed primarily in chief cells of parathyroid glands where, when activated by high Ca2+ concentrations, it decreases PTH release (calcium-retaining hormone) to maintain Ca2 +. Alternatively, under hypocalcemia conditions, CaSR is inactive and PTH is released which restores normocalcemia by acting on kidney as well as intestine to increase Ca2 + absorption, and on bone, to mobilise skeletal Ca2 +. CaSR is also expressed in other tissues which do not play an obvious role in Ca2 + homeostasis (breast, blood vessels, liver, and placenta) and altered CaSR expression and/or activity have been found associated with parathyroid glands disorders, osteoporosis, vascular calcification and cancer. CaSR is implicated in regulation of diverse processes that includes hormone secretion, gene expression, ion channel activity, modulation of inflammation, proliferation, differentiation, and apoptosis, depending on cell type, and therefore, represents a key molecule in physiology. Defects in CaSR have been linked to familial hypocalciuric hypercalcemia type 1 (FHH), neonatal severe primary hyperparathyroidism (NSHPT), familial isolated hypoparathyroidism (FIH) and epilepsy, idiopathic generalized type 8 (EIG8).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 2 applications: FLOW, WB.

Showing Publications 1 - 6 of 6.

Publications using NB100-1830	Applications	Species
Papadopoulou A, Gole E, Moutafi A et al. Calcium sensing receptor in pregnancies complicated by gestational diabetes mellitus Placenta. 2014-06-02 [PMID: 24930987] (WB, Human) Details: Calcium Sensing Receptor antibody (clone HL 1499) used for WB in placentas from healthy women and the pregnancies complicated by gestational diabetes mellitus (GDM) - CaSR expression was found to be lowered in GDM group when compared to healthy placentas.	WB	Human
Awata H et al. Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein. J Biol Chem;276(37):34871-9. 2001-09-14 [PMID: 11390379]
Handlogten ME et al. The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway. J Biol Chem;276(17):13941-8. 2001-04-27 [PMID: 11278341]
Szalat A, Benhamron S, Galitzer H et al. Treatment-Resistant Auto-Immune Hypoparathyroidism Associated with Celiac Disease. 90th Annual Meeting of the Endocrine Society (ENDO); San Francisco, CA; USA. 2008-06-15
Wu W, Lee S, Chiang B et al. Urothelial Calcium-Sensing Receptor Modulates Micturition Function via Mediating Detrusor Activity and Ameliorates Bladder Hyperactivity in Rats Pharmaceuticals 2021-09-23 [PMID: 34681183] (Rat)		Rat
Liu L, Awoyemi AA, Fahy KE et al. Keratinocyte-derived microvesicle particles mediate Ultraviolet B radiation induced systemic immunosuppression The Journal of clinical investigation 2021-04-08 [PMID: 33830943] (FLOW, Human)	FLOW	Human

Array NB100-1830

• Calcium-sensing R/CaSR Antibodies
• Calcium-sensing R/CaSR ELISA Kits
• Calcium-sensing R/CaSR Lysate
• Calcium-sensing R/CaSR Proteins
• Calcium-sensing R/CaSR Proteins and Enzyme