BRIP1/FANCJ Antibody (pp15-IB4)

FANCJ (Fanconi anemia group J protein) was originally identified as a protein which binds BRCT domains of BRCA1 and was named BACH1 (BRCA1-Associated C-terminal Helicase1) or BRIP1 (BRCA1 Interacting Protein C-terminal Helicase1), and after its identification as a component of Fanconi anemia pathway, it was renamed as FANCJ. It is expressed ubiquitously with highest levels in testes and sub-cellularly, it localizes to the nucleus. FANCJ is a DNA-dependent ATPase with 5' to 3' DNA helicase activity which is essential for genetic and structural integrity of genome. FANCJ acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination, and is implicated in repairing DNA double-strand breaks through homologous recombination in FANCJ-BRCA1 interactions dependent manner. Cell-cycle regulated phosphorylation of FANCJ is essential for BRCA1 interaction and 4Fe-4S iron-sulfur-binding is required for its helicase activity. The interaction of FANCJ with proteins including MutLalpha complex and BRCA1, suggests its importance in other pathways of DNA repair and in diseases such as colon and breast cancer. Defective FANCJ causes chromosome instability disorder Fanconi anemia complementation group J.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IP, WB.

Showing Publications 1 - 4 of 4.

Publications using NB100-189	Applications	Species
Xi H, Gao YH, Han DY et al. Hypoxia inducible factor-1a suppresses Peroxiredoxin 3 expression to promote proliferation of CCRCC cells. FEBS Lett. 2014-08-02 [PMID: 25093297]
Kim JM, Kee Y, Gurtan A et al. Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. Blood 2008-05-01 [PMID: 18174376]
Cannavo, E et al. Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2. J Biol Chem;282(5):2976-86. 2007-02-02 [PMID: 17148452] (WB, Human)	WB	Human
Cantor, S et al. BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell;105(1):149-60. 2001-04-06 [PMID: 11301010] (IP, Human)	IP	Human

Array NB100-189

• BRIP1/FANCJ Antibodies
• BRIP1/FANCJ Lysate
• BRIP1/FANCJ Protein