BMP-4 Antibody (66119) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

BMP4 is a TGF beta superfamily ligand that is widely expressed from early embryogenesis through adulthood. It plays an important role in mesenchyme formation, epidermal determination, suppression of neural induction, the development of multiple organs, and tissue repair (1 5). The human BMP4 precursor contains a 273 amino acid (aa) propeptide and a 116 aa mature protein (6). Processing of the propeptide by furin or proprotein convertase 6 enables the formation of the mature disulfidelinked homodimeric BMP4 and facilitates its secretion. Similar intracellular processes may lead to the formation and recreation of BMP4/BMP7 disulfidelinked heterodimer (7 9). Mature human and mouse BMP4 share 98% aa sequence identity. Human BMP4 shares 85% aa sequence identity with human BMP2 and less than 50% with other human BMPs. Compared to BMP4 homodimers, BMP4/ BMP7 heterodimers exhibit a greater potency in inducing osteogenic differentiation (9). In Xenopus, the heterodimers can also induce the formation of mesoderm, whereas BMP4 homodimers only provide ventralizing signals for existing mesoderm (10). BMP4 signals through tetrameric complexes composed of type I (primarily Activin RIA or BMPRIA) and type II (primarily Activin RIIA or BMPRII) receptors (11, 12). The bioavailability of BMP4 is regulated by its interaction with multiple proteins and glycosaminoglycan (13 - 15).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Ovine.

We have publications tested in 5 applications: IHC-Fr, IHC-P, Immunoprecipitation, Neutralization, Western Blot.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using MAB757	Applications	Species
J Liu, Z Liu, J Zhang, X Chen, J Chen, L Sui, J Yu Ibrutinib Inhibits Angiogenesis and Tumorigenesis in a BTK-Independent Manner Pharmaceutics, 2022-09-05;14(9):. 2022-09-05 [PMID: 36145624] (Neutralization, Human)	Neutralization	Human
L Dupays, N Towers, S Wood, A David, DJ Stuckey, T Mohun Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function PLoS ONE, 2019-03-06;14(3):e0212992. 2019-03-06 [PMID: 30840660] (Western Blot, Mouse)	Western Blot	Mouse
AK Patel, K Vipparthi, V Thatikonda, I Arun, S Bhattachar, R Sharan, P Arun, S Singh A subtype of cancer-associated fibroblasts with lower expression of alpha-smooth muscle actin suppresses stemness through BMP4 in oral carcinoma Oncogenesis, 2018-10-05;7(10):78. 2018-10-05 [PMID: 30287850] (Neutralization, Human)	Neutralization	Human
N Blanchette, D Kita, A Konstorum, L Tesfay, D Lemler, P Hegde, KP Claffey, FM Torti, SV Torti Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer Oncogene, 2018-04-26;37(29):4013-4032. 2018-04-26 [PMID: 29695834] (Neutralization, Human)	Neutralization	Human
Susanna Canali, Chia-Yu Wang, Kimberly B. Zumbrennen-Bullough, Abraham Bayer, Jodie L. Babitt Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6 American Journal of Hematology 11/1/2017 [PMID: 28815688]
C Sallon, I Callebaut, I Boulay, J Fontaine, D Logeart-Av, C Henriquet, M Pugnière, X Cayla, P Monget, G Harichaux, V Labas, S Canepa, C Taragnat Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells J. Biol. Chem., 2017-07-26;0(0):. 2017-07-26 [PMID: 28747434] (Immunoprecipitation, Western Blot, Human, Ovine)	Immunoprecipitation, Western Blot	Human, Ovine
Silvia Calpe, Ana C. P. Correia, Maria del Carmen Sancho-Serra, Kausilia K. Krishnadath Comparison of newly developed anti-bone morphogenetic protein 4 llama-derived antibodies with commercially available BMP4 inhibitors mAbs 5/18/2016 [PMID: 26967714]
Eric E. Nilsson, Ginger Larsen, Michael K. Skinner Roles of Gremlin 1 and Gremlin 2 in regulating ovarian primordial to primary follicle transition REPRODUCTION 6/1/2014 [PMID: 24614542]
Herrera B, Inman GJ A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol., 2009-03-19;10(0):20. 2009-03-19 [PMID: 19298647] (Neutralization, Human)	Neutralization	Human
Jeanpierre S, Nicolini FE, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, Maguer-Satta V BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood, 2008-07-29;112(8):3154-63. 2008-07-29 [PMID: 18664625] (Neutralization, Human)	Neutralization	Human
Kane R, Godson C, O'Brien C Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis. Mol. Vis., 2008-06-20;14(0):1138-48. 2008-06-20 [PMID: 18587495] (Western Blot, Human)	Western Blot	Human
Zode GS, Clark AF, Wordinger RJ Activation of the BMP canonical signaling pathway in human optic nerve head tissue and isolated optic nerve head astrocytes and lamina cribrosa cells. Invest. Ophthalmol. Vis. Sci., 2007-11-01;48(11):5058-67. 2007-11-01 [PMID: 17962458] (Western Blot, Human)	Western Blot	Human
Fuller ML, DeChant AK, Rothstein B, Caprariello A, Wang R, Hall AK, Miller RH Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. Ann. Neurol., 2007-09-01;62(3):288-300. 2007-09-01 [PMID: 17696121] (IHC-Fr, Rat)	IHC-Fr	Rat
Bleuming SA, Kodach LL, Garcia Leon MJ, Richel DJ, Peppelenbosch MP, Reitsma PH, Hardwick JC, van den Brink GR Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach. J. Pathol., 2006-06-01;209(2):190-7. 2006-06-01 [PMID: 16550632] (IHC-P, Human)	IHC-P	Human
Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, Bautch VL, Conlon FL, Patterson C BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol. Cell. Biol., 2003-08-01;23(16):5664-79. 2003-08-01 [PMID: 12897139] (Neutralization, Human)	Neutralization	Human
van den Brink GR, Hardwick JC, Tytgat GN, Brink MA, Ten Kate FJ, Van Deventer SJ, Peppelenbosch MP Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. Gastroenterology, 2001-08-01;121(2):317-28. 2001-08-01 [PMID: 11487541] (IHC-P, Human, Mouse)	IHC-P	Human, Mouse
Show All 16 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Human	04/04/2020	View Summary Application Western Blot Sample Tested breast cancer MCF7 cells,BT-20 human breast cancer cell line Species Human Lot CEO011901B

Array MAB757

• BMP-4 Antibodies
• BMP-4 ELISA Kits
• BMP-4 Lysates
• BMP-4 Proteins
• BMP-4 Proteins and Enzymes
• BMP-4 ELISAs