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BMI-1 Antibody [CoraFluor™ 1]

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Product Details

Summary
Reactivity Hu, Mu, Bv, Ch, Fe, PmSpecies Glossary
Applications WB, IHC, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
CoraFluor 1

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB100-87026AF350
Alexa Fluor 405
NB100-87026AF405
Alexa Fluor 488
NB100-87026AF488
Alexa Fluor 532
NB100-87026AF532
Alexa Fluor 594
NB100-87026AF594
Alexa Fluor 647
NB100-87026AF647
Alexa Fluor 700
NB100-87026AF700
Alexa Fluor 750
NB100-87026AF750
Allophycocyanin
NB100-87026APC
Biotin
NB100-87026B
DyLight 350
NB100-87026UV
DyLight 405
NB100-87026V
DyLight 488
NB100-87026G
DyLight 550
NB100-87026R
DyLight 594
NB100-87026DL594
DyLight 650
NB100-87026C
DyLight 680
NB100-87026FR
DyLight 755
NB100-87026IR
FITC
NB100-87026F
HRP
NB100-87026H
Janelia Fluor 525
NB100-87026JF525
Janelia Fluor 549
NB100-87026JF549
Janelia Fluor 585
NB100-87026JF585
Janelia Fluor 635
NB100-87026JF635
Janelia Fluor 646
NB100-87026JF646
Janelia Fluor 669
NB100-87026JF669
PE
NB100-87026PE
PerCP
NB100-87026PCP
Unconjugated
NB100-87026
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BMI-1 Antibody [CoraFluor™ 1] Summary

Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
Immunogen
The immunogen recognized by this antibody maps to a region between residue 276 and 326 of human B lymphoma Mo-MLV insertion region 1 homolog using the numbering given in entry NP_005171.4 (GeneID 648).
Predicted Species
Chicken (100%), Primate (100%), Bovine (100%), Feline (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
BMI1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Cat (100%), Orangutan (100%).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Purity
Immunogen affinity purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for BMI-1 Antibody [CoraFluor™ 1]

  • B lymphoma Mo-MLV insertion region 1 homolog (mouse)
  • B lymphoma Mo-MLV insertion region 1 homolog
  • BMI1 polycomb ring finger oncogene
  • BMI1
  • BMI-1
  • FLVI2/BMI1
  • MGC12685
  • murine leukemia viral (bmi-1) oncogene homolog
  • PCGF4
  • polycomb complex protein BMI-1
  • polycomb group protein Bmi1
  • polycomb group ring finger 4
  • RING finger protein 51
  • RNF51
  • RNF51Polycomb group RING finger protein 4

Background

Bmi1 polycomb ring finger oncogene regulates the cell cycle inhibitor genes p16 and p19, with implications in hematopoiesis, skeletal patterning, neurological functions, and development of the cerebellum. Bmi 1 has been shown to induce telomerase activity and immortalize human mammary epithelial cells, and extend the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi-1 is also required for efficient self-renewing cell division in adult hematopoietic and neural stem cells.

Aberrant expression of Bmi-1 has been found in several types of cancer in the bladder, skin, blood, prostate, breast, ovaries, andcolon. Its overexpression is especially pronounced in mantle cell lymphomas. Thereforem Bmi1 antibodies will be useful tools for many cancer development studies.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Hu, Mu
Applications: Flow-IC, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB
CTLA-4
[Unconjugated]
7268-CT
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(3 Publications)
Species: Hu
Applications: BA
BMI-1 Antibody
[CoraFluor™ 1]
NB100-87026CL1
BMI-1 Antibody [CoraFluor™ 1]
Species: Hu, Mu, Bv, Ch, Fe, Pm
Applications: WB, IHC, IP

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Bioinformatics

Gene Symbol BMI1