beta-III Tubulin Antibody (TU-20) [Alexa Fluor® 405]

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Beta-III Tubulin is abundant in the central and peripheral nervous systems where it is prominently expressed during fetal and postnatal development. Beta III Tubulin is often referred to as TUJ1 because Tuj-1 is the clone name of the original monoclonal antibody. The Tuj1 clone is such a popular neuronal marker that Tuj-1 is now used as a synonym for beta III tubulin. The distribution of Tubulin Beta 3 is neuron-associated, exhibiting distinct temporospatial gradients according to the regional neuroepithelia of origin. However, transient expression of the Tubulin Beta 3 protein is also present in the subventricular zones of the CNS comprising putative neuronal- and/or glial precursor cells, as well as in Kulchitsky neuroendocrine cells of the fetal respiratory epithelium. This temporally restricted, potentially non-neuronal expression may have implications in the identification of presumptive neurons derived from embryonic stem cells. Mutation on beta-tubulin has been linked to anti-cancer drug resistance in lung cancers.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: FLOW, ICC/IF.

Showing Publications 1 - 2 of 2.

Publications using NB600-1018AF405	Applications	Species
Leupold L, Sigutova V, Gerasimova E et al. The Quest for Anti-?-Synuclein Antibody Specificity-Lessons Learnt From Flow Cytometry Analysis Frontiers in neurology 2022-07-15 [PMID: 35911883] (ICC/IF) Details: AF488-conjugate. Flow: 2 ug per test, ICC/IF: 1:100 dilution, WB: 1:500 dilution	ICC/IF
Krach F, Wheeler EC, Regensburger M Et al. Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis Acta Neuropathol 2022-07-01 [PMID: 35778567] (FLOW, Human) Details: Citation using the Alexa Fluor 405 version of this antibody.	FLOW	Human

Array NB600-1018AF405

• beta-III Tubulin Antibodies
• beta-III Tubulin ELISA Kits
• beta-III Tubulin Lysate
• beta-III Tubulin Protein