beta-III Tubulin Antibody (TU-20) [FITC]

Tubulin is the major building block of microtubules. This intracellular cylindrical filamentous structure is present in almost all eukaryotic cells. Microtubules function as structural and mobile elements in mitosis, intracellular transport, flagellar movement, and the cytoskeleton. Except in the simplest eukaryotes, tubulin exists in all cells as a mixture of similar, but not identical, sets of alpha and beta tubulin polypeptides. Within either set of polypeptides, individual subunits diverge from each other (both within and across species) at less than 10% of the amino acid positions. The most extreme diversity is localized to the 15 residues of the carboxy terminal. For beta tubulin five evolutionarily conserved isotype clones have been identified. These are almost totally conserved in the subunits utilized in the same cell types of different species, with the exception of the hematopoietic beta tubulin which is the most highly divergent in sequence and is not conserved between species. Research has been centered around the hypothesis that these beta tubulin isotypes contribute to unique functional properties. It has been reported that the different isotypes of tubulin differ from each other in their ability to polymerize into microtubules. The monoclonal antibody from hybridoma SDL.3D10 can stimulate microtubule assembly when reconstituted with tubulin, tau or MAP2

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 7 of 7.

Publications using NB500-620	Applications	Species
Jirasek T, Cipro S, Musilova A et al. Expression of class III beta-tubulin in colorectal carcinomas: an immunohistochemical study using TU-20 & TuJ-1 antibody Indian J Med Res 2009-01-01 [PMID: 19287064] Details: This citation used the FITC version of this antibody.
Theodorou E, Dalembert G, Heffelfinger C et al. A high throughput embryonic stem cell screen identifies Oct-2 as a bifunctional regulator of neuronal differentiation Genes Dev 2009-03-01 [PMID: 19270158] Details: This citation used the FITC version of this antibody.
Katsetos CD, Draberova E, Smejkalova B et al. Class III beta-Tubulin and gamma-Tubulin are Co-expressed and form Complexes in Human Glioblastoma Cells Neurochem Res 2007-01-01 [PMID: 17406983] Details: This citation used the FITC version of this antibody.
Jirasek T, Pisarikova E, Viklicky V, Mandys V. Expression of class III beta-tubulin in malignant epithelial tumours: an immunohistochemical study using TU-20 and TuJ-1 antibodies Folia Histochem Cytobiol 2007-01-01 [PMID: 17378245] Details: This citation used the FITC version of this antibody.
Kukharskyy V, Sulimenko V, Macurek L et al. Complexes of gamma-tubulin with nonreceptor protein tyrosine kinases Src and Fyn in differentiating P19 embryonal carcinoma cells Exp Cell Res 2004-08-01 [PMID: 15242776] Details: This citation used the FITC version of this antibody.
Peknicova J, Kubatova A, Sulimenko V et al. Differential subcellular distribution of tubulin epitopes in boar spermatozoa: recognition of class III beta-tubulin epitope in sperm tail Biol Reprod 2001-09-01 [PMID: 11514327] Details: This citation used the FITC version of this antibody.
Draberova E, Lukas Z, Ivanyi D et al. Expression of class III beta-tubulin in normal and neoplastic human tissues Histochem Cell Biol 1998-03-01 [PMID: 9541471] Details: This citation used the FITC version of this antibody.

Array NB500-620

• beta-III Tubulin Antibodies
• beta-III Tubulin Lysate
• beta-III Tubulin Protein