beta-1,3-Glucuronyltransferase 1/B3GAT1 Antibody (1056734) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

B3GAT1 is a key enzyme involved in human natural killer-1 (HNK-1) epitope synthesis. It adds a glucuronic residue to the terminal lactosamine residue (Gal beta 1-4GlcNAc-) of a glycoprotein or glycolipid, which can be further sulfated to become the HNK-1 epitope, a unique trisaccharide structure, HSO3-3GlcA beta 1-3Gal beta 1-4GlcNAc- (1, 2). The enzyme activity was found to be enhanced in the presence of sphingomyelin and phosphatidylinositol (3).The HNK-1 carbohydrate epitope is characteristically expressed on a series of cell adhesion molecules in addition to some glycolipids in the extracellular matrix and on the cell surface in the nervous system, where it is involved in cell‑cell and cell‑substratum interaction and recognition during the development of the nervous system (4). Like most known glycosyltransferases, B3GAT1 is a type II Golgi-resident transmembrane protein with a short N‑terminal cytoplasmic domain and a single‑pass transmembrane domain followed by an enzymatic domain in the lumen of Golgi apparatus. The enzyme activity was assayed using a phosphatase-coupled method (5).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB85603

• beta-1,3-Glucuronyltransferase 1/B3GAT1 Antibodies
• beta-1,3-Glucuronyltransferase 1/B3GAT1 ELISA Kits
• beta-1,3-Glucuronyltransferase 1/B3GAT1 Lysate
• beta-1,3-Glucuronyltransferase 1/B3GAT1 Proteins
• beta-1,3-Glucuronyltransferase 1/B3GAT1 Proteins and Enzyme