beta-1,3-Glucuronyltransferase 1/B3GAT1 Antibody (1002707) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

B3GAT1 is a key enzyme involved in human natural killer1 (HNK1) epitope synthesis. It adds a glucuronic residue to the terminal lactosamine residue (Gal beta 14GlcNAc) of a glycoprotein or glycolipid, which can be further sulfated to become the HNK1 epitope, a unique trisaccharide structure, HSO₃-3GlcA beta 1-3Gal beta 1-4GlcNAc (1, 2). The enzyme activity was found to be enhanced in the presence of sphingomyelin and phosphatidylinositol (3). The HNK1 carbohydrate epitope is characteristically expressed on a series of cell adhesion molecules in addition to some glycolipids in the extracellular matrix and on the cell surface in the nervous system, where it is involved in cell-cell and cell-substratum interaction and recognition during the development of the nervous system (4). Like most known glycosyltransferases, B3GAT1 is a type II Golgi-resident transmembrane protein with a short N-terminal cytoplasmic domain and a single pass transmembrane domain followed by an enzymatic domain in the lumen of Golgi apparatus. The enzyme activity was assayed using a phosphatase-coupled method (5).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB8560

• beta-1,3-Glucuronyltransferase 1/B3GAT1 Antibodies
• beta-1,3-Glucuronyltransferase 1/B3GAT1 ELISA Kits
• beta-1,3-Glucuronyltransferase 1/B3GAT1 Lysate
• beta-1,3-Glucuronyltransferase 1/B3GAT1 Proteins
• beta-1,3-Glucuronyltransferase 1/B3GAT1 Proteins and Enzyme