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BAFFR/TNFRSF13C Antibody (2403C) [Alexa Fluor® 488]

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Product Details

Summary
Applications Flow
Clone
2403C
Clonality
Monoclonal
Host
Rabbit
Conjugate
Alexa Fluor 488

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB1162U-100UG
Alexa Fluor 405
FAB1162V-100UG
Alexa Fluor 532
FAB1162X
Alexa Fluor 594
FAB1162T-100UG
Alexa Fluor 647
FAB1162R-100UG
Alexa Fluor 700
FAB1162N-100UG
Alexa Fluor 750
FAB1162S-100UG
Allophycocyanin
FAB11621A
Allophycocyanin/Cy7
FAB1162APCCY7
Biotin
FAB1162B
CoraFluor 1
FAB1162CL1
DyLight 350
FAB1162D
DyLight 405
FAB1162E
DyLight 488
FAB1162K
DyLight 550
FAB1162L
DyLight 594
FAB1162M
DyLight 650
FAB1162W
DyLight 680
FAB1162Y
DyLight 755
FAB1162Z
FITC
FAB1162F
HRP
FAB1162H
Janelia Fluor 525
FAB1162JF525
Janelia Fluor 549
FAB1162I
Janelia Fluor 585
FAB1162JF585
Janelia Fluor 635
FAB1162JF635
Janelia Fluor 646
FAB1162J
Janelia Fluor 669
FAB1162JF669
PE
FAB11621P
PE/Atto594
FAB1162PEATT594
PE/Cy5.5
FAB1162PECY55
PE/Cy7
FAB1162PECY7
PerCP
FAB1162C
Unconjugated
MAB1162-100
mFluor Violet 450 SE
FAB1162MFV450
mFluor Violet 500 SE
FAB1162MFV500
mFluor Violet 610 SE
FAB1162MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB1162-100
Carrier Free
MAB1162-100
Carrier Free
MAB1162-SP
Carrier Free
FAB1162V-100UG
Carrier Free
FAB1162U-100UG
Carrier Free
FAB1162T-100UG
Carrier Free
FAB1162S-100UG
Carrier Free
FAB1162R-100UG
Carrier Free
FAB1162N-100UG
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BAFFR/TNFRSF13C Antibody (2403C) [Alexa Fluor® 488] Summary

Additional Information
Recombinant Monoclonal Antibody.
Immunogen
Mouse myeloma cell line, NS0-derived human BAFF R/TNFRSF13C
Ser7-Ala71
Accession # Q96RJ3
Specificity
Detects human BAFF R/TNFRSF13C in direct ELISAs.
Source
N/A
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Purity Statement
Protein A or G purified from cell culture supernatant
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Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

B-cell activating factor (BAFF), also known as BlyS, TALL-1, TNAK, and zTNF4, is a TNF ligand superfamily member and has been designated TNFSF13B. Produced by macrophages, dendritic cells, and T lymphocytes, BAFF promotes the survival of B cells and is essential for B cell maturation (1-4). BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF. The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain (CRD) and contains only a partial CRD with four cysteine residues. Human and mouse BAFF R share 56% aa sequence identity. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cell, in resting CD4+ T cells, in thymus and peripheral blood leukocytes. BAFF knockout mice lack mature B cells. Similarly, A/WySnJ mice that are defective in BAFF-R intracellular signaling also lack mature B cells, suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis. In contrast, BCMA- or TACI-deficient mice have no major defect in B-cell development. While the function of BCMA is not defined, TACI has been shown to control B-cell homeostasis and T-cell-independent immune responses.

  1. Rolink, A.G. and F. Melcher (2002) Curr. Opin. Immunol. 14:266.
  2. Mackay F. and J.L. Browning (2002) Nature Reviews Immunology 2:464.
  3. Laabi, Y. et al. (2001) Current Biol. 11:R1013.
  4. Thompson, J.S. et al. (2001) Science 14:2108.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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BAFFR/TNFRSF13C
Antibody (2403C) [Ale ...
FAB1162G
BAFFR/TNFRSF13C Antibody (2403C) [Alexa Fluor® 488]
Species: Hu
Applications: Flow

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