HeLa human cervical epithelial carcinoma cell line was stained with Mouse Anti-Human Axl PE-conjugated Monoclonal Antibody (Catalog # FAB154P, filled histogram) or isotype control antibody (Catalog # IC002P, open ...read more
A431 human epithelial carcinoma cell line was stained with PE-conjugated Mouse Anti-Human Axl Monoclonal Antibody (Catalog # FAB154P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). ...read more
Genetic Strategies: Axl knockout A431 human epithelial carcinoma cell line was stained with PE-conjugated Mouse Anti-Human Axl Monoclonal Antibody (Catalog # FAB154P, filled histogram) or isotype control antibody ...read more
Mouse myeloma cell line NS0-derived recombinant human Axl Met1-Pro440 Accession # AAA61243
Specificity
Detects human Axl in direct ELISAs. In direct ELISAs, this antibody shows no cross-reactivity with recombinant mouse Axl, recombinant human (rh) Dtk or rhMer.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
AXL
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Axl Antibody (108724) [Phycoerythrin]
AI323647
ARK
AXL oncogene
AXL receptor tyrosine kinase
AXL transforming sequence/gene
Axl
EC 2.7.10
EC 2.7.10.1
JTK11
Tyro7
tyrosine-protein kinase receptor UFO
UFO
UFOoncogene AXL
Background
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt), and Mer (human and mouse homologues of chicken c-Eyk) constitute a subfamily of the receptor tyrosine kinases (1,2). The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. The human Axl cDNA encodes an 887 amino acid (aa) precursor that includes an 18 aa signal sequence, a 426 aa extracellular domain, a 21 aa transmembrane segment, and a 422 aa cytoplasmic domain. The extracellular domains of human and mouse Axl share 81% aa sequence identity. A short alternately spliced form of human Axl is distinguished by a 9 aa deletion in the extracellular juxtamembrane region. These receptors bind the vitamin K-dependent protein growth arrest specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis (3). This family of tyrosine kinase receptors is involved in hematopoiesis, embryonic development, tumorigenesis, and regulation of testicular functions.
Yanagita, M. (2004) Curr. Opin. Nephrol. Hypertens. 13:465.
Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
Holland, S. et al. (2005) Canc. Res. 65:9294.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.
=
÷
Review this Product
Be the first to review our Axl Antibody (108724) [Phycoerythrin] and receive a gift card or discount.