ATP2C2 Antibody - BSA Free

ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Images	Ratings	Applications	Species	Date	Details
Enlarge	3 reviewed by: Scott Messenger	ICC	Human	12/15/2017	View Summary Application Immunocytochemistry Sample Tested LS180 human colorectal adenocarcinoma cell line Species Human Lot 6289-1101
Enlarge	3 reviewed by: Scott Messenger	WB	Human	12/15/2017	View Summary Application Western Blot Sample Tested LS180 human colorectal adenocarcinoma cell line Species Human Lot 6289-1101

Array NBP1-76567

• ATP2C2 Antibodies
• ATP2C2 Lysate
• ATP2C2 Proteins