PMCA4 Antibody (JA9)

The protein encoded by the PMCA4 gene belongs to the family of P-type primary ion transport ATPases characterized by theformation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ionsfrom eukaryotic cells against very large concentration gradients and play a critical role in intracellular calciumhomeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and thediversity of these enzymes is further increased by alternative splicing of transcripts. The expression of differentisoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting thatthese pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes theplasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms havebeen identified. (provided by RefSeq)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: ICC/IF, IP, KD, WB.

Showing Publications 1 - 10 of 10.

Publications using NB300-569	Applications	Species
Hwang JY, Chai P, Nawaz S et al. LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility bioRxiv : the preprint server for biology 2023-06-10 [PMID: 36865175] (WB, Mouse) Details: 1 ug/ml dilution	WB	Mouse
Bian S, Zhang X, Lin L et al. Exosomal MiR-4261 mediates calcium overload in RBCs by downregulating the expression of ATP2B4 in multiple myeloma Frontiers in Oncology 2022-08-26 [PMID: 36091107]
Yeh YC, Lin YP, Kramer H, Parekh AB Single nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression Hum. Mol. Genet. 2019-10-10 [PMID: 31600783] (WB, KD, IP, Human)	WB, KD, IP	Human
Grabek A, Dolfi B, Klein B et al. Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility Cell 2019-05-30 [PMID: 31056283] (WB, Human)	WB	Human
Carvajal-Maldonado D, Byrum AK, Jackson J et al. Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing Nucleic Acids Res. 2018-06-18 [PMID: 29917110] (WB, Human)	WB	Human
Ma CT, Chyau CC, Hsu CC et al. Pepino polyphenolic extract improved oxidative, inflammatory and glycative stress in the sciatic nerves of diabetic mice. Food Funct. 2016-01-21 [PMID: 26791916] (WB, Mouse)	WB	Mouse
Chung JJ, Shim SH, Everley RA et al. Structurally distinct ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell. 2014-05-08 [PMID: 24813608] (ICC/IF, Mouse)	ICC/IF	Mouse
Chen JH, Tsai CW, Wang CP, Lin HH. Anti-atherosclerotic potential of gossypetin via inhibiting LDL oxidation and foam cell formation. Toxicol Appl Pharmacol 2013-07-08 [PMID: 23845592] (WB, Mouse)	WB	Mouse
Chen JH, Wang CJ, Wang CP et al. Hibiscus sabdariffa leaf polyphenolic extract inhibits LDL oxidation and foam cell formation involving up-regulation of LXRalpha/ABCA1 pathway. Food Chem. 2013-11-01 [PMID: 23768373] (WB, Mouse)	WB	Mouse
Ritchie MF, Samakai E, Soboloff J. STIM1 is required for attenuation of PMCA-mediated Ca(2+) clearance during T-cell activation. The EMBO Journal. 2012-01-13 [PMID: 22246182]

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	WB	Human	11/23/2011	View Summary Application Western Blot Sample Tested Human Species Human

Array NB300-569

• PMCA4 Antibodies
• PMCA4 Lysate
• PMCA4 Protein