ARID1A Antibody

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Zebrafish.

We have publications tested in 4 applications: Block/Neutralize, Chemotaxis, WB, Western Blot.

Showing Publications 1 - 5 of 5.

Publications using NB100-55334	Applications	Species
Yakovlev VA, Sullivan SA, Fields EC, Temkin SM. PARP inhibitors in the treatment of ARID1A mutant ovarian clear cell cancer: PI3K/Akt1-dependent mechanism of synthetic lethality Frontiers in Oncology 2023-02-22 [PMID: 36910637] (Western Blot, Block/Neutralize)	Western Blot, Block/Neutralize
Shi H, Tao T, Abraham B et al. ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression Sci. Adv. 2020-07-01 [PMID: 32832616] (WB, Zebrafish)	WB	Zebrafish
Bullard WL, Kara M, Gay LA et al. Identification of murine gammaherpesvirus 68 miRNA-mRNA hybrids reveals miRNA target conservation among gammaherpesviruses including host translation and protein modification machinery PLoS Pathog. 2019-08-01 [PMID: 31393953] (WB, Mouse)	WB	Mouse
Castillo-Robles J, Ramirez L, Spaink HP, Lomeli H. smarce1 mutants have a defective endocardium and an increased expression of cardiac transcription factors in zebrafish. Sci Rep. 2018-10-18 [PMID: 30337622] (Chemotaxis, Zebrafish)	Chemotaxis	Zebrafish
Wurster AL, Precht P, Pazin MJ et al. NF-?B and BRG1 bind a distal regulatory element in the IL-3/GM-CSF locus. Mol Immunol 2011-09-01 [PMID: 21831442]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Other	03/23/2015	View Summary Application Western Blot Sample Tested zebrafish embryos Species Other
Enlarge	4 reviewed by: Xiaofeng Wang	WB	Mouse	02/28/2014	View Summary Application Western Blot Sample Tested mouse embryonic fibroblasts nuclear extract Species Mouse Lot 1

Array NB100-55334

• ARID1A Antibodies
• ARID1A Lysate
• ARID1A Proteins