ARID1A Products

Description

ARID1A encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain ARID1A genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.

Bioinformatics

Entrez	8289 Human
Uniprot	NP_006006 Human NP_006006.3 Human O14497 Human
Product By Gene ID	8289
Alternate Names	ARID domain-containing protein 1A AT rich interactive domain 1A (SWI- like) AT rich interactive domain 1A (SWI-like) AT-rich interactive domain-containing protein 1A B120SWI-like protein BAF250a BAF250A BAF250SWI/SNF complex protein p270 BM029 brain protein 120 BRG1-associated factor 250 BRG1-associated factor 250a C10rf4 C1orf4SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatinsubfamily F member 1 chromatin remodeling factor p250 hELD hOSA1 matrix associated, actin dependent regulator of chromatin Osa homolog 1 OSA1 nuclear protein OSA1 P270 SMARCF1 subfamily f, member 1

Research Areas for ARID1A

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Signal Transduction