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APPL Antibody (OTI4B11) [DyLight 350]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications IHC
Clone
OTI4B11
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 350

Order Details

APPL Antibody (OTI4B11) [DyLight 350] Summary

Immunogen
Full length recombinant protein of human APPL (NP_036228) produced in HEK293T cells.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
APPL1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for APPL Antibody (OTI4B11) [DyLight 350]

  • Adapter protein containing PH domain, PTB domain and leucine zipper motif 1
  • adaptor protein containing pH domain, PTB domain and leucine zipper motif 1
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zippercontaining 1
  • AKT2 interactor
  • APPL
  • APPL1
  • APPLdip13-alpha
  • DCC-interacting protein 13-alpha
  • DIP 13 alpha
  • DIP13A
  • DIP13alpha
  • Dip13-alpha
  • KIAA1428
  • signaling adaptor protein DIP13alpha

Background

APPL is encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

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Calculators

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Bioinformatics

Gene Symbol APPL1