APAF-1 Antibody - BSA Free

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1). Apaf1 binds to cytochrome c (Apaf-2) and caspase-9 (Apaf-3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 is ubiquitously expressed in human tissues.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 applications: ELISA, IP.

Showing Publications 1 - 3 of 3.

Publications using NBP1-77000	Applications	Species
Marwarha G, Rosand o, Scrimgeour N et al. miR-210 Regulates Apoptotic Cell Death during Cellular Hypoxia and Reoxygenation in a Diametrically Opposite Manner Biomedicines 2021-12-25 [PMID: 35052722] (IP, ELISA)	IP, ELISA
Tsujimoto K, Ono T, Sato M et al. Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis. J Biol Chem. 2005-07-29 [PMID: 15944155]
Ikezoe K, Nakagawa M, Yan C et al. Apoptosis is suspended in muscle of mitochondrial encephalomyopathies. Acta Neuropathol. 2002-06-01 [PMID: 12012084]

Array NBP1-77000

• APAF-1 Antibodies
• APAF-1 ELISA Kits
• APAF-1 Lysate
• APAF-1 Proteins