alpha Endosulfine Antibody

alpha Endosulfine is encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. alpha Endosulfine is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Zebrafish.

We have publications tested in 1 application: IF/IHC.

Showing Publication 1 - 1 of 1.

Publication using NBP2-13963	Applications	Species
Yi Z, Ouyang J, Sun W et al. Comparative exome sequencing reveals novel candidate genes for retinitis pigmentosa EBioMedicine 2020-05-23 [PMID: 32454406] (IF/IHC, Zebrafish)	IF/IHC	Zebrafish

Array NBP2-13963

• alpha Endosulfine Antibodies
• alpha Endosulfine Lysates
• alpha Endosulfine Proteins