CENPB Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 4 of 4.

Publications using H00001059-B01P	Applications	Species
Kitagawa R, Niikura Y, Becker A et al. EWSR1 maintains centromere identity Cell reports 2023-05-25 [PMID: 37243594]
Niikura Y, Fang L, Kitagawa R et al. Mass Spectrometry Analysis to Identify Ubiquitylation of EYFP-tagged CENP-A (EYFP-CENP-A) J Vis Exp 2020-06-10 [PMID: 32597847]
Niikura Y, Kitagawa R, Fang L, Kitagawa K CENP-A Ubiquitylation Is Indispensable to Cell Viability Dev. Cell 2019-09-23 [PMID: 31550462]
Niikura Y, Kitagawa R, Ogi H, Kitagawa K. SGT1-HSP90 complex is required for CENP-A deposition at centromeres Cell Cycle 2017-08-17 [PMID: 28816574]

Array H00001059-B01P

• CENPB Antibodies
• CENPB ELISA Kits
• CENPB Proteins