alpha 2-Macroglobulin Antibody

Alpha 2 macroglobulin is a serum protein which is mainly synthesised in the liver. It functions as a broad range irreversible proteinase inhibitor that forms a "trap" around most proteases. Alpha 2 macroglobulin is is a tetrameric molecule, and with a molecular weight of 720 kDa, it so large a molecule that it tends to remain intravascular. Following conformational change, the protinase is deposited within a central cavity where it is still active but prevented from further contact with its substrate. Removal of the complex is mediated by the generation of recognition sites which react with receptors on a variety of cells including macrophages and liver cells. Alpha 2 macroglobulin is localized on the surface of peripheral blood lymphocytes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using NBP1-85491	Applications	Species
Kato BS, Nicholson G, Neiman M et al. Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model. Proteome Sci 2011-11-17 [PMID: 22093360]
Haggmark A, Neiman M, Drobin K et al. Classification of protein profiles from antibody microarrays using heat and detergent treatment. N Biotechnol 2012-06-01 [PMID: 22023822]

Array NBP1-85491

• alpha 2-Macroglobulin Antibodies
• alpha 2-Macroglobulin ELISA Kits
• alpha 2-Macroglobulin Lysate
• alpha 2-Macroglobulin Protein
• alpha 2-Macroglobulin ELISA
• alpha 2-Macroglobulin Proteins and Enzyme