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ALK-7/Activin Receptor Type 1C Antibody [Unconjugated]

Name: ALK-7/Activin Receptor Type 1C Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF7749
Price: 469 USD

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ALK‑7 was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using Sheep Anti-Human ALK‑7 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7749) at 15 µg/mL ...read more

Product Details

Summary

Reactivity	HuSpecies Glossary
Applications	IHC
Host	Sheep
Conjugate	Unconjugated

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Catalog# & Formulation	Size	Price
Carrier Free AF7749-SP

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ALK-7/Activin Receptor Type 1C Antibody [Unconjugated] Summary

Immunogen	Chinese hamster ovary cell line CHO-derived recombinant human ALK‑7 Met1-Glu113 Accession # Q8NER5
Specificity	Detects human ALK‑7 in direct ELISAs.
Source	N/A
Isotype	IgG
Host	Sheep
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Applications/Dilutions

Dilutions

Immunohistochemistry 10-25 ug/mL

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ALK-7/Activin Receptor Type 1C Antibody [Unconjugated]

activin A receptor, type IC
Activin receptor type IC
activin receptor type-1C
Activin receptor-like kinase 7
Activin RIC
ACTR-IC
ACVR1C
ACVRLK7
ALK7
ALK-7
ALK7ALK-7
EC 2.7.11
EC 2.7.11.30

Background

Activin receptor-like kinase 7 (ALK-7), also known as Activin R1C (gene name ACVR1C), is a glycosylated 58 kDa type I receptor in the superfamily of TGF-beta serine/threonine kinase receptors. It associates with type II receptors to form a signaling complex that responds to the ligands Activin AB, and Activin B, GDF3, and Nodal. ALK-7 plays a role in regulating energy balance by inhibiting insulin secretion and inducing pancreatic beta cell apoptosis. It is expressed in adipose tissue but downregulated in obesity. ALK-7 is also expressed in pituitary gonadotropic cells and in pre-eclamptic placenta. It induces the apoptosis of trophoblasts as well as ovarian granulosa and epithelial cells. Within the extracellular domain, human ALK-7 shares 95% and 91% amino acid (aa) sequence identity with mouse and rat ALK-7, respectively. Alternate splicing of human ALK-7 generates additional isoforms with either a 50 aa N-terminal truncation or with deletions of 79 aa or 157 aa that encompass the transmembrane segment.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Sheep IgG Isotype Control [Unconjugated]
5-001-A

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Bioinformatics

Uniprot

Q8NER5()

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

ALK-7/Activin Receptor Type 1C Antibody [Unconjugated]

Species Glossary

Images

Product Details

Order Details

ALK-7/Activin Receptor Type 1C Antibody [Unconjugated] Summary

Applications/Dilutions

Packaging, Storage & Formulations

Notes

Alternate Names for ALK-7/Activin Receptor Type 1C Antibody [Unconjugated]

Background

Limitations

Customers Who Viewed This Item Also Viewed...

Publications for ALK-7/Activin Receptor Type 1C Antibody (AF7749) (0)

Reviews for ALK-7/Activin Receptor Type 1C Antibody (AF7749) (0)

FAQs for ALK-7/Activin Receptor Type 1C Antibody (AF7749) (0)

Secondary Antibodies

Isotype Controls

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