ADAMTS4 Antibody

ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. ADAMTS4 lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NBP1-54369	Applications	Species
Tatar M, Uslu S, Öner J Expression of placental growth factor and a disintegrin and metalloprotease with a thrombospondin type motifs 1-4-8 during the three trimesters of rat pregnancy at the maternal-fetal interface Anatomia, histologia, embryologia 2023-07-09 [PMID: 37424113]
Gagliardi F, Narayanan A, Gallotti AL, et al. Enhanced SPARCL1 expression in cancer stem cells improves preclinical modeling of glioblastoma by promoting both tumor infiltration and angiogenesis Neurobiol. Dis. 2019-12-10 [PMID: 31830525] (WB, Mouse)	WB	Mouse

Array NBP1-54369

• ADAMTS4 Antibodies
• ADAMTS4 ELISA Kits
• ADAMTS4 Lysate
• ADAMTS4 Proteins
• ADAMTS4 ELISA
• ADAMTS4 Proteins and Enzyme