Activin RIA/ALK-2/Activin Receptor Type 1 Antibody Summary
| Immunogen |
A synthetic peptide corresponding to amino acids 475-525 of human ACVR1 was used as immunogen. |
| Isotype |
IgG |
| Clonality |
Polyclonal |
| Host |
Rabbit |
| Gene |
ACVR1 |
| Purity |
Protein G purified |
| Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
| Dilutions |
|
| Application Notes |
In human kidney, additional bands are seen at approximately 27 and 14 kD. |
| Control |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Buffer |
PBS containing 0.2% gelatin. |
| Preservative |
0.05% Sodium Azide |
| Concentration |
0.5 mg/ml |
| Purity |
Protein G purified |
Alternate Names for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody
Background
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Publications for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (NB100-56432) (0)
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Product General Protocols
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Video Protocols
FAQs for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (NB100-56432) (0)
Control Lysate(s)
Secondary Antibodies
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Isotype Controls
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