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Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5)

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Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5) [H00000090-M07] - Analysis of ACVR1 expression in transfected 293T cell line by ACVR1 monoclonal antibody (M07), clone 2D5. Lane 1: ACVR1 transfected lysate (Predicted MW: 57.2 KDa). Lane 2: Non-transfected lysate.
Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5) [H00000090-M07] - Analysis of ACVR1 expression in transfected 293T cell line by ACVR1 monoclonal antibody (M07), clone 2D5. Lane 1: ACVR1 ...read more
ELISA: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5) [H00000090-M07] - Detection limit for recombinant GST tagged ACVR1 is 0.03 ng/ml as a capture antibody.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA
Clone
2D5
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5) Summary

Description
Quality control test: Antibody Reactive Against Recombinant Protein.
Immunogen
ACVR1 (AAH33867, 21 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
Specificity
Reacts with activin A receptor, type I.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
ACVR1
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Western Blot
Application Notes
This antibody is reactive against recombinant protein in WB and ELISA.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
In 1x PBS, pH 7.4
Preservative
No Preservative
Purity
Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5)

  • activin A receptor, type I
  • Activin RIA
  • ActivinRIA
  • ACTRI
  • ACVR1
  • ACVR1A
  • ACVRLK2
  • ALK2
  • ALK-2
  • FOP
  • SKR1
  • TSRI

Background

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ACVR1
Entrez
Uniprot